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姓名	鄭世偉(Shi-Wei Zheng)  查詢紙本館藏	畢業系所	光電科學與工程學系
論文名稱	實驗室晶片整合之設計與製作
相關論文	★ 新型光電生化感測器之分析與研究 ★ 薄膜電晶體液晶顯示器中視角色偏之優化補償方法 ★ 特定色度背光模組零組件之光學特性評估 ★ 電子紙增亮分析與模擬設計 ★ 生物晶片螢光檢測之光源模型探討 ★ 介電電濕式數位微流體驅動系統之探討 ★ 發光二極體照明系統之色彩特性優化設計 ★ 以EWOD為基礎的長鏈高分子原位合成器 ★ 色盲量化測試系統之研究 ★ 可調式自然日光模擬光源之製作 ★ 演色性評估之相關性指標 ★ 亞精胺影響下DNA構形與DNA碎片分佈之研究 ★ 生物晶片之螢光光學檢測 ★ 生物晶片螢光分析之微光學模組 ★ 光學式生化反應即時偵測系統 ★ 微液滴驅動之研究與探討
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摘要(中)	在生命科學與醫學研究中，樣品的分析通常包括三個典型步驟，即：樣品分離處理、生物化學反應、結果檢測和分析。現今的實驗室晶片通常只具有執行單一步驟的能力，因此在進行樣品的分析的實驗時，常常需要將專門的樣品晶片、反應晶片、檢測晶片以及微泵和微閥門等元件結合，這不僅耗時、耗費成本而且也可能對實驗造成影響。 　　因此，本研究提出將驅動器與感測器結合的概念，將介電質電濕式(electrowetting on dielectric, EWOD)微流體系統與導模共振(guided-mode resonance)感測整合至微小晶片上，並且利用整合後的晶片來進行不同濃度的蔗糖液滴訊號量測實驗。由實驗結果得知，本研究製作的晶片不僅成功的將驅動器與感測器結合，而且還能做到動態與即時的量測效果。
摘要(英)	In life science and medicine research, the assay of the testing samples includes three steps : sample preparation、biochemistry reaction、examination and analysis. Currently, the biochips working with single function require other device such as sample chips、reaction chips、assay chips、micro pump、micro-valve and so on, to perform experiments on assay of the testing sample that are time-consuming and money-wasting. In this work, we propose the concept about integration of actuator and sensor, so the electro-wetting on dielectric (EWOD) micro-fluidic system is integrated with guide-mode resonance (GMR) sensors for the assay of sucrose aqueous solution. The optical spectrum analyzer (OSA) data reveals that the integrated chip works normally, also can achieve in-situ detection.
關鍵字(中)	★ 介電質電濕式驅動 ★ 導模共振式光學感測	關鍵字(英)	★ GMR ★ EWOD
論文目次	第一章 緒論 1 1.1 生物晶片簡介 3 1.2 生物晶片功能 6 1.2.1 介電質電濕式驅動(EWOD) 6 1.2.2 EWOD的應用實例 9 1.3 研究動機 15 第二章 原理 16 2.1 驅動模組 16 2.2 感測模組 22 第三章 晶片的製作 27 3.1 驅動模組的製作 27 3.2 感測模組的製作 32 3.3 系統整合 40 第四章 實驗量測結果與討論 50 4.1 不同濃度的蔗糖水溶液偵測實驗 50 4.2 量測結果與討論 53 第五章 結論 60 參考文獻 62
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指導教授	楊宗勳(Tsung-Hsun Yang)	審核日期	2009-7-23
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