多波長光源與應用於血氧濃度探測之研究

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姓名

鍾雙兆(Shuang-Chao Chung) 查詢紙本館藏

畢業系所

光電科學與工程學系

論文名稱

多波長光源與應用於血氧濃度探測之研究
(The research of multi wavelength light source and its application in pulse oximeter)

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摘要(中)

在本論文中，我們應用LED光源窄頻與可靠性高之優點，首先完成一多波長調變之光源，探討多波長光源於生物組織之傳播行為之差異。然後，我們建立一可靠有效的光學皮膚模型，使用蒙地卡羅光追跡之方式，模擬光於皮膚組織吸收與散射差異之特性，研究光於生物組織之能量傳遞行為，進而了解入射光在通過組織後，光被皮膚組織吸收和散射之現象，進而優化系統之效率。此研究方式透過電腦模擬，可有效了解光於生物組織可能之行為，提供更精確之光學系統設計，進而改良傳統反射式血氧飽合測定儀效率低之缺點。
本論文中，我們提出一新型式的反射式血氧飽合濃度系統，利用一菲涅爾透鏡來重新調制光入射待測生物組織的光學傳播行為，完成一高效能之反射式血氧濃度感測器。此新型血氧感測器可在在低訊號身體部位(如手腕)量測出血氧訊號，並且準確度達到醫療等級之水準。此項研究相信能對反射式血氧飽合濃度計之效率與準確性有所提升，使得非侵入式的生醫檢測有著更廣範之應用。

摘要(英)

Photoplethysmography (PPG) is a useful technique that widely used to monitor blood changes which induced by cardiac pulsations. Pulse oximer uses this technique of PPG to estimate arterial blood oxygen saturation values (SpO2) and pulse rate (PR). In this thesis, a new reflective pulse oximeter is proposed and demonstrated with implanting a Fresnel lens, which enhances the reflected signal. An optical simulation model incorporated with human skin characteristics is presented to evaluate the capability of the new reflected optical system. Based on the skin model, the new prototype is optimized and realized. Compared with the other reflective oximeters, the reflected signal light detected by the photodiode is effectively enhanced. The prototype was able to accurately measure within an error of + 3% for SpO2 and PR respectively from the wrist.

關鍵字(中)

★ 血氧飽和濃度
★ 血氧計
★ 光體積變化描記圖
★ 皮膚模型

關鍵字(英)

★ SpO2
★ Pulse Oximeter
★ PPG
★ Skin Model

論文目次

目錄
摘要 I
Abstract II
致謝 III
目錄 VI
圖索引 X
表索引 XIII
第一章緒論 1
1-1 光譜學與技術發展 1
1-2 研究動機 2
1-3 文獻探討 4
1-4 論文大綱與安排 5
第二章 LED基礎原理介紹 7
2-1 LED發光原理及發光特性 8
2-2 光學色彩特徵參數 10
2-2-1 色座標 10
2-2-2 色溫 11
2-2-3 演色性 12
2-3 不同光波長光於介質之差異 14
2-3-1 LED光源 14
2-3-2 光學系統 15
2-3-3 電路控制系統 16
2-3-4 範例一：非生物組織之光學特性差異 17
2-3-5 範例二：心律檢測 19
2-4 結論 20
第三章皮膚組織光學基礎原理介紹 22
3-1 生物組織之光學特性 23
3-1-1 光於皮膚組織的傳播行為穿透、反射、吸收與散射 25
3-1-2 光在生物組織的散射傳播 27
3-2 皮膚光學模型 29
3-2-1 蒙地卡羅光線追跡法 29
3-2-2 皮膚模型建立流程與模擬參數 30
3-3 結論 33
第四章多波長光源運用於血氧濃度探測之研究 34
4-1 血氧濃度器原理 36
4-2 反射式血氧濃度器光學系統之研究 41
4-2-1 光源與光偵測器之選擇 41
4-2-2 光源波長飄移對血氧訊號之影響 45
4-2-3 LED與PD距離對AC、DC和PI之影響(模擬與實驗) 46
4-3 新型反射式血氧濃度設計 51
4-4 結論 54
第五章反射式血氧飽合測定儀之製作與實驗結果 55
5-1 新型反射式血氧濃度器製作 55
5-1-1 光源與PD 55
5-1-2 Fresnel透鏡製作 56
5-2 實驗系統與量測結果 58
5-2-1 光源模型配光曲線分布 58
5-2-2 皮膚模型實驗驗證 60
5-2-3 市售產品之比較 63
5-3 血氧數值之準確度測試 64
5-4 臨床驗證 67
5-5 結論 69
第六章結論 70
6-1 結論 70
6-2 未來展望 71
參考文獻 73
中英文名詞對照表 78
個人著作列表 86

參考文獻

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指導教授

孫慶成(Ching-Cherng Sun)

審核日期

2016-7-25

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