| 摘要(英) |
Precise neural firing is important in the transferring of information. However, we still do not fully understand the mechanism that allows neurons to generate a spike within a narrow temporal regime in the order of a few millisecond. To study the spike timing in a neuron, we perform two types of experiment. Firstly, we stimulate the neuron with different temporal correlated stimuli using patch clamp, and analyze the statistics of corresponding firing patterns; secondly, we apply the stochastic optimal control to manipulate the spiking time. Our samples are from the primary cortical culture. Our result indicates that precision of spike timing is optimal when the correlation times of stimuli are from 2 to 10 ms. In the ramp stimuli experiment, the higher slope of ramp stimuli result in higher precision of spike timing. Obviously, the precision of spike timing depends on stimulus transients. In the stochastic optimal control experiment, the spike timing can be controlled within a few millisecond(1~5ms). |
| 參考文獻 |
[1] Chichilnisky, E. J., and R. S. Kalmar. "Temporal resolution of ensemble visual motion signals in primate retina." The Journal of neuroscience 23.17 (2003): 6681-6689.
[2] Borst, Alexander, and Frédéric E. Theunissen. "Information theory and neural coding." Nature neuroscience 2.11 (1999): 947-957.
[3] Mainen, Zachary F., and Terrence J. Sejnowski. "Reliability of spike timing in neocortical neurons." Science 268.5216 (1995): 1503-1506.
[4] Iolov, Alexandre, Susanne Ditlevsen, and André Longtin. "Stochastic optimal control of single neuron spike trains." Journal of neural engineering 11.4 (2014): 046004.
[5] Verveen, A. A. "On the fluctuation of threshold of the nerve fibre." Structure and function of the cerebral cortex (1960): 282-288.
[6] Verveen, A. A., and H. E. Derksen. "Fluctuation phenomena in nerve membrane." Proceedings of the IEEE 56.6 (1968): 906-916.
[7] Pozzorini, Christian, et al. "Temporal whitening by power-law adaptation in neocortical neurons." Nature neuroscience 16.7 (2013): 942-948.
[8] Stuehmer, Walter, et al. "Structural parts involved in activation and inactivation of the sodium channel." Nature 339.6226 (1989): 597-603.
[9] Parri, H. Rheinallt, and Vincenzo Crunelli. "Sodium current in rat and cat thalamocortical neurons: role of a non-inactivating component in tonic and burst firing." The Journal of neuroscience 18.3 (1998): 854-867.
[10] Adrian, Edgar Douglas. "The impulses produced by sensory nerve endings. "The Journal of physiology 61.1 (1926): 49-72.
[11] Fuglevand, ANDREW J., DAVID A. Winter, and AFTAB E. Patla. "Models of recruitment and rate coding organization in motor-unit pools." Journal of neurophysiology 70.6 (1993): 2470-2488.
[12] Nabi, Ali, et al. "Minimum energy desynchronizing control for coupled neurons." Journal of computational neuroscience 34.2 (2013): 259-271.
[13] Hamill, Owen P., et al. "Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches." Pflügers Archiv 391.2 (1981): 85-100.
[14] Berecki, Géza, et al. "Dynamic clamp as a tool to study the functional effects of individual membrane currents." Patch-Clamp Methods and Protocols (2014): 309-326.
[15] Destexhe, Alain, et al. "Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons." Neuroscience 107.1 (2001): 13-24.
[16] Aldrich, Richard W., and Charles F. Stevens. "Voltage-dependent gating of single sodium channels from mammalian neuroblastoma cells." The Journal of neuroscience 7.2 (1987): 418-431.
[17] Scanley, B. E., et al. "Kinetic analysis of single sodium channels from canine cardiac Purkinje cells." The Journal of general physiology 95.3 (1990): 411-437.
[18] Vandenberg, CAROL A., and R. I. C. H. A. R. D. Horn. "Inactivation viewed through single sodium channels." The Journal of general physiology 84.4 (1984): 535-564.
[19] White, John A., Jay T. Rubinstein, and Alan R. Kay. "Channel noise in neurons." Trends in neurosciences 23.3 (2000): 131-137.
[20] Fernandez, Fernando R., Paola Malerba, and John A. White. "Non-linear Membrane Properties in Entorhinal Cortical Stellate Cells Reduce Modulation of Input-Output Responses by Voltage Fluctuations." PLoS Comput Biol 11.4 (2015): e1004188.
[21] Connors, B. W., M. J. Gutnick, and D. A. Prince. "Electrophysiological properties of neocortical neurons in vitro." Journal of Neurophysiology 48.6 (1982): 1302-1320.
[22] Ratté, Stéphanie, et al. "Impact of neuronal properties on network coding: roles of spike initiation dynamics and robust synchrony transfer." Neuron78.5 (2013): 758-772.
[23] Rodriguez-Molina, Victor M., Ad Aertsen, and Detlef H. Heck. "Spike timing and reliability in cortical pyramidal neurons: effects of EPSC kinetics, input synchronization and background noise on spike timing." PloS one 2.3 (2007): e319.
[24] Berger, Thomas, Matthew E. Larkum, and Hans-R. Lüscher. "High I h channel density in the distal apical dendrite of layer V pyramidal cells increases bidirectional attenuation of EPSPs." Journal of neurophysiology85.2 (2001): 855-868.
[25] Yamauchi, Satoshi, Hideaki Kim, and Shigeru Shinomoto. "Elemental spiking neuron model for reproducing diverse firing patterns and predicting precise firing times." (2011).
[26] Mensi, Skander, et al. "Enhanced Sensitivity to Rapid Input Fluctuations by Nonlinear Threshold Dynamics in Neocortical Pyramidal Neurons." PLoS Comput Biol 12.2 (2016): e1004761. |
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