乾燥綜合症與非病毒型肝炎之相關因子分析

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姓名

湯先昀(Xian-Yun Tang) 查詢紙本館藏

畢業系所

系統生物與生物資訊研究所

論文名稱

乾燥綜合症與非病毒型肝炎之相關因子分析
(Factor analysis of relationships between Sjögren′s syndrome and non-viral hepatitis)

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摘要(中)

乾燥綜合症與肝臟疾病之間的關聯性已在 1954 年被提出，至今已有不少文獻指出
乾燥症與病毒型肝炎有強烈關聯性，然而探討乾燥症與非病毒型肝炎之文獻相對甚少，
在本研究中，我們將分析國泰醫院及壢新醫院之看診資料，同時以健保資料庫為輔，分
析乾燥症患者與非病毒型肝炎之相關性。進而發現乾燥症患者有較高的機率被診斷出肝
炎（ICD9-CM：573.3）以及慢性肝炎（ICD9-CM：571.40）（P-value: 6.29E-14－2.82E
123），接著我們提出幾個假設因子：溫溼度、性別、年齡、乾燥症類型、藥物使用，以
了解何種因素會提升乾燥症患者罹患非病毒型肝炎之風險，研究結果顯示，溫溼度、性
別以及乾燥症類型並不會影響乾燥症患者罹患非病毒型肝炎之比率（P-value > 0.05）。然
而在年齡上，50 到 70 歲之乾燥症患者較易罹患非病毒型肝炎。在用藥部分，大多數藥
物服用後都會使乾燥症患者比無乾燥症患者更容易罹患非病毒型肝炎，且部分藥物服用
次數越高，肝炎復發次數將隨之提升。

摘要(英)

Association between Sjögren′s syndrome (SjS) and liver disease was indicated in 1954. Up to now, many studies have indicated that SjS and viral-hepatitis are correlated. However, association between SjS and non-viral hepatitis was rarely studied. In this study, we used clinical data from Cathay General Hospital and Landseed Hospital and supplemented by NHIRD to analyse the association between SjS and non-viral hepatitis. We found that SjS patients was usually diagnosed with hepatitis (ICD9-Codes: 573.3) and chronic hepatitis (ICD9-Codes: 571.40) (P-value: 6.29E-14 to 2.82E-123). To understand what factors elevated the prevalence of hepatitis in patients with SjS, we supposed the following factors of rising diagnosis: temperature, humidity, gender, age, types of SjS and medicines. The result shows that temperature, humidity, gender and types of SjS do not impact on prevalence of hepatitis in adult patients with SjS (P-value >0.05). However, 50 to 70 year-olds’ patients have higher prevalence of hepatitis. Most of medicines elevate the risk of hepatitis, and patients take more medicines, the prevalence of hepatitis are also higher in adult SjS patients.

關鍵字(中)

★ 乾燥症
★ 非病毒型肝炎
★ 生物資訊

關鍵字(英)

★ Sjögren′s syndrome
★ Non-viral hepatitis
★ Bioinformatics

論文目次

中文摘要 i
English Abstract ii
Tables of content iii
List of figures v
List of tables vi
List of appendix vii
Chapter 1 Introduction 1
1-1 Background 1
1-2 Related work 1
1-3 Motivation 2
1-3 Goal 2
Chapter 2 Materials and Methods 3
2-1 Collection of clinical data 3
2-2 Collection of climate data 3
2-3 Data processing 3
2-4 Procedure of research 4
2-4-1 Identifying association between SjS and climate 4
2-4-2 Finding association between SjS patients and the other disease 4
2-4-3 Suspicious factor analysis 7
2-4-4 Statistics methods 8
Chapter 3 Results 9
3-1 Finding association between SjS and climate 9
3-2 Identifying association between SjS patients and the other disease 9
3-2-1 Factor: climate 9
3-2-2 Factor: age 9
3-2-3 Factor: gender 10
3-2-4 Factor: type of SjS 10
3-2-5 Factor: medicine 10
Chapter 4 Discussion and Conclusion 22
4-1 Association between SjS and temperature and humidity 22
4-2 Climate, gender and type of SjS 22
4-3 Ages 23
4-4 Medicines 23
4-6 Conclusion 24
Appendix 26
References 32

參考文獻

1. Brito-Zeron, P., et al., Sjogren syndrome. Nat Rev Dis Primers, 2016. 2: p. 16047. 2. Price, E. and P. Venables, Dry eyes and mouth syndrome—a subgroup of patients presenting with sicca symptoms. Rheumatology, 2002. 41(4): p. 416-422. 3. Ramos-Casals, M., et al., Google-driven search for big data in autoimmune geoepidemiology: analysis of 394,827 patients with systemic autoimmune diseases. Autoimmun Rev, 2015. 14(8): p. 670-9. 4. Rasmussen, A., et al., Previous diagnosis of Sjögren’s Syndrome as rheumatoid arthritis or systemic lupus erythematosus. Rheumatology, 2016. 55(7): p. 1195-1201. 5. Gotkine, M. and O. Abramsky, SLE, rheumatoid arthritis, and Sjögren’s syndrome. International Neurology, Second Edition, 2016: p. 75-82. 6. Cristiansson, J., CORNEAL CHANGES IN A CASE OF HEPATITIS. Acta Ophthalmologica, 1954. 32(2): p. 161-164. 7. Perz, J.F., et al., The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. Journal of hepatology, 2006. 45(4): p. 529-538. 8. Chang, M.S. and M.H. Nguyen, Epidemiology of Hepatitis B and the Role of Vaccination. Best Practice & Research Clinical Gastroenterology, 2017. 9. Chang, M.-H., et al., Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. New England Journal of Medicine, 1997. 336(26): p. 1855-1859. 10. World-Health-Organization. What is hepatitis? 2016 [cited 2017 July 18]; Available from: http://www.who.int/features/qa/76/en/. 11. Baldini, C., et al., Classification criteria for Sjogren’s syndrome: A critical review. Journal of Autoimmunity, 2012. 39(1): p. 9-14. 12. Ohira, H., K. Abe, and A. Takahashi, Involvement of the liver in rheumatic diseases. Clinical Journal of Gastroenterology, 2012. 5(1): p. 9-14. 13. Zeron, P.B., et al., Diagnosis of Liver Involvement in Primary Sjögren Syndrome. Journal of Clinical and Translational Hepatology, 2013. 1(2): p. 94-102. 14. Haddad, J., et al., Lymphocytic sialadenitis of Sjogren′s syndrome associated with chronic hepatitis C virus liver disease. Lancet, 1992. 339(8789): p. 3213. 15. Sheu, J.-C., et al., Prevalence of hepatitis C viral infection in a community in Taiwan: Detection by synthetic peptide-based assay and polymerase chain reaction. Journal of hepatology, 1993. 17(2): p. 192-198. 16. Yeh, C.C., et al., Association of Sjogrens Syndrome in Patients with Chronic Hepatitis Virus Infection: A Population-Based Analysis. PLoS One, 2016. 11(8): p. e0161958. 17. Chang, M.-H., Breakthrough HBV infection in vaccinated children in Taiwan: surveillance for HBV mutants. Antiviral therapy, 2010. 15(3): p. 463. 18. Miller MH, et al., The liver in systemic lupus erythematosus. The Quarterly journal of medicine, 1984. 53(211): p. 401-9. 19. Andrade, R.J., et al., Drug-Induced Liver Injury: An Analysis of 461 Incidences Submitted to the Spanish Registry Over a 10-Year Period. Gastroenterology, 2005. 129(2): p. 512-521.

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20. Karp, J.K., E.K. Akpek, and R.A. Anders, Autoimmune hepatitis in patients with primary Sjögren′s syndrome: a series of two-hundred and two patients. International Journal of Clinical and Experimental Pathology, 2010. 3(6): p. 582-586. 21. Pearson, K., Note on Regression and Inheritance in the Case of Two Parents. Proceedings of the Royal Society of London, 1895. 58: p. 240-242. 22. Fisher, R.A., On the Interpretation of X^2 from Contingency Tables, and the Calculation of P. Journal of the Royal Statistical Society, 1922. 85(1): p. 87-94. 23. Horwitz, R.I., A method of estimating comparative rates from clinical data: Applications to cancer of the lung, breast, and cervix. Journal of Chronic Diseases. 32(1): p. i. 24. Neyman, J., Outline of a Theory of Statistical Estimation Based on the Classical Theory of Probability. Philosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences, 1937. 236(767): p. 333-380. 25. Pearson, K., X.On the criterion that a given system of deviations from the probable in the case of a correlated system of variables is such that it can be reasonably supposed to have arisen from random sampling. Philosophical Magazine Series 5, 1900. 50(302): p. 157-175. 26. Spearman, C., The Proof and Measurement of Association between Two Things. The American Journal of Psychology, 1904. 15(1): p. 72-101. 27. Steel, R.G.D. and J.H. Torrie, Principles and procedures of statistics; with special reference to the biological sciences. 1960. 28. Alvarez, F., et al., International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. Journal of Hepatology. 31(5): p. 929-938. 29. 黃素鈴, et al., 台灣地區職業型態與飲酒行為之相關分析 — 2005 年國民健康訪問暨藥物濫用調查 . 2011, 國民健康訪問調查. 30. 林忠潁, et al., 台灣地區酒精使用型態與醫療使用行為之關係探討 . 台灣公共衛生雜誌, 2014. 33(2): p. 197-208. 31. Carey, W.D. Autoimmune Hepatitis. 2015 [cited 2017 July 18]; Available from: http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/hepatology/c hronic-autoimmune-hepatitis/#references. 32. Paul Kowal and Karen Peachey, Indicators for the Minimum Data Set Project on Ageing: A Critical Review in sub-Saharan Africa. 2001. 33. Jay H. Hoofnagle, et al. DRUG RECORD HYDROXYCHLOROQUINE. 2017 [cited 2017 July 28]; Available from: https://livertox.nih.gov/Hydroxychloroquine.htm#reference. 34. Jay H. Hoofnagle, et al. DRUG RECORD AZATHIOPRINE. 2017 [cited 2017 July 28]; Available from: https://livertox.nlm.nih.gov/Azathioprine.htm. 35. Hoofnagle, J.H., et al., LiverTox: A Web Site on Drug Induced Liver Injury. Hepatology (Baltimore, Md.), 2013. 57(3): p. 873-874.

指導教授

吳立青(Li-Ching Wu)

審核日期

2017-7-14

推文