| 摘要(英) |
Chinese traditional Chinese medicine has been underestimated by Western modern science, but with the different compounds extracted from various Chinese medicines used to treat diseases which have good effects, therefore, in recent years, Chinese medicine has attracted more and more attention in the medical field. According to ancient Chinese medical literature, Chinese drug are classified into three attribution: cold, medium and heat medicine; Chinese medicine is also classified as Meridian which means that the drug belongs to the meridians it affects. In this study, we attempted to explain the differences between the attribution and meridian of traditional Chinese medicine by analyzing the L1000 expression profile data of cancer cells treated with Chinese drug. After data analysis, we found that functional analysis of differences between various attributes, tastes, and meridian showed different functions between different groups. In addition, we have learned that the pathways leading to the action of cells in some specific properties may affect the development of cancer. Based on this result, we selected four TCMs which mix the attributes and meridians of our interest and we proved three of these drug’s ability of inhibiting MCF7 breast cancer cells through cell biology experiments. Finally, we believe that the results of Chinese medicine classification method studies that explain by the L1000 profile data may be useful for the development of Chinese medicine. |
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