以作者查詢圖書館館藏

、以作者查詢臺灣博碩士

、以作者查詢全國書目

、勘誤回報

、線上人數：62

、訪客IP：18.188.13.127

姓名	莊馥瑞(FU-RUEI JHUANG)  查詢紙本館藏	畢業系所	生物物理研究所
論文名稱	non (A minimal model of the distribution of proliferative cells, flow field, and pressure in a monolayer epithelial tissue)
相關論文	★ 鍺銻碲相變化奈米薄膜之奈米尺度光熱性質的研究 ★ 波在一維系統中的傳播與局域化 ★ 生物膜黏著引發的相分離—等效膜勢與數值模擬 ★ 非平衡生物膜上的區塊形成 ★ 液滴上的彈性網絡 ★ 受體配體叢集在外力下的理論研究 ★ 兩板間黏著叢集的強度 ★ 粒子黏著於生物膜所引發的細胞攝入作用之物理研究 ★ 黏著叢集在時變外力下的強度 ★ 滲透壓對單層巨型微胞的影響 ★ 模擬被clathrin蛋白質覆蓋的板塊狀胞吞作用 ★ T細胞受體活化反應之模型 ★ Modeling geometrical trajectories of actin-based motility ★ 隨機布耳網路在多連線且臨界情形下的特性 ★ 模擬脂質雙層膜上的分子機器 ★ 組織動力學之建模
檔案	[Endnote RIS 格式]    [Bibtex 格式]    [相關文章]   [文章引用]   [完整記錄]   [館藏目錄]   [檢視]  [下載] 本電子論文使用權限為同意立即開放。 已達開放權限電子全文僅授權使用者為學術研究之目的，進行個人非營利性質之檢索、閱讀、列印。 請遵守中華民國著作權法之相關規定，切勿任意重製、散佈、改作、轉貼、播送，以免觸法。
摘要(中)	上皮組織通常是由增生細胞和分化細胞組成且在組織中的細胞的結構是分層結構。在這篇論文當中我們提出了一個理論的模型用來研究有不同形狀的上皮組織，並且我們可以從這個模型得到穩定的和成長中的上皮組織中的增生細胞的分布、流場和壓力。除此之外我們證明了細胞的分裂、分化和死亡對組織中細胞的分布、流場和壓力有著重要的影響。而特別的是組織中的壓力當在增生細胞區和分化細胞區之間時會因為突然快速變化的細胞分化率而產生一個極小值。
摘要(英)	Epithelial tissues are composed of proliferative cells and differentiated cells and the distribution of these cells inside the tissue often shows stratified structure. In this thesis, we propose a theoretical model to study monolayer epithelial tissues with different shapes. We show that within our model it is easy to calculate the distribution of proliferative cells, the flow field and the pressure in both steady state tissues and growing tissues. We show that cell events such as cell division, cell differentiation and apoptosis are important in shaping the distribution of cells, flow field, and pressure in the tissue. In particular, the pressure field around the transition region between the proliferative cell niche and differentiated cell niche shows a local minimum due to the sudden change of flow field caused by the spatially fast-varying cell differentiation rate.
關鍵字(中)	★ 上皮組織 ★ 生物組織 ★ 細胞 ★ 上皮的	關鍵字(英)	★ epithelium ★ tissue ★ cell ★ epithelial
論文目次	Contents 1 Introduction 1 1.1 Biological background . . . . . . . . . . . . . . . 1 1.2 Motivation . . . . . . . . . . . . . . . . . . . . 5 2 The model 6 2.1 Theoretical model . . . . . . . . . . . . . . . . . 6 2.2 One-dimensional periodic tissue pattern . . . . . . 7 2.2.1 Periodic tissue pattern in one dimension . . . . .7 2.2.2 Result and discussion of one-dimensional periodic tissue pattern . . . . . . . . . . . . . . . . . . . . .9 3 Two-dimensional steady state tissue pattern with rotational symmetry 17 3.1 An isolated tissue monolayer with rotational symmetry. . . . . . . . . . . . . . . . . . . . . . . .17 3.2 Result and discussion for a tissue in two dimensions . . . . . . . . . . . . . . . . . . . . . . . . . . . .18 4 Time evolution of a growing tissue 26 4.1 Time evolution of a growing tissue . . . . . . . . 26 5 Conclusion 29
參考文獻	[1] W.G. Hale, J.P. Margham, V.A. Saunders, Harper Collins Dictionary of Biology (HarperCollins Publishers Limits, 1991). [2] Cambridge Dictionary, (https://dictionary.cambridge.org/dictionary/english/epithelium). [3] (https://en.wikipedia.org/wiki/Epithelium). [4] Tianchi Xin, Valentiana Greco and Peggy Myung, Hardwiring Stem Cell Communication through Tissue Structure, Cell, 164, 1212 (2016). [5] A.D. Lander, K.K. Gokoski, A.L. Calof, et al, Cell Lineages and the Logic of Proliferative Control, PLoS Biology, 7, 84 (2009). [6] Boris I. Shralman, Mechanical feedback as a possible regulator of tissue growth, PNAS., 102, 3318 (2005). [7] Stacy R. Finkbeiner, et al, Generation of tissue-engineered small intestine using embryonic stem cellderived human intestinal organiods, Biology Open 4, 1462 (2015). [8] Charlene Guillot, Thomas Lecuit, Mechanics of Epithelial Tissue Homeostasis and Morphogenesis, Science, 340, 1185 (2013). [9] A. L. Calof, et alJ. Neurobiol., 36(2):190, (1998). [10] I. H. Smart. J. Anat., 109:243, (1971). [11] Hannezo, Prost, Joanny, J. R. Soc. Interface, 11, 20130895 (2014). [12] P. Tracqui, Biophysical models of tumour growth, Report on Progress in Physics, 72(2009) 056701. [13] Victor D, Varner, Jason P. Gleghorn, et al., Mechanically patterning the embryonic airway epithelium, PNAS, 112, 9230 (2015). [14] Gabriel Fenteany, Paul A. Janmey, and Thomas P. Stossel, Signaling pathways and cell mechanics involved in wound closure by epithelial cell sheets, Current Biology, 10, 831 (2000). [15] Wei-Ting Yeh, Hsuan-Yi Chen., A minimal spatial cell lineage model of epithelium: tissue stratiction and multi-stability, New Journal of Physics., Vol 20 (2018). [16] Edouard Hannezo, Alice Coucke, Jean-Francois, Joanny, Inter of migratory and division forces as a generic mechanism for stem cell patterns, Physical Review, 93,022405 (2016). [17] Marcelo R. Ebert, Michael Reissig, Methods for Partial Dierential Equations: Qualitative Properties of Solutions, Phase Space Analysis, Semilinear Models (Springer International Publishing: Imprint: Birkhauser, (2018). [18] Philip Nelson, Biological Physics: Energy, Information, Life (W H Freeman and Co, 2007). [19] A.E. Shyer et al, Villication: How the Gut Gets Its Villi, Science, 342, 212 (2013). [20] M. C. Marchetti, J. F. Joanny et al, Hydrodynamics of soft active matter, Review of Modern Physics, 85, 1143 (2013). [21] James M. Wells, Jason R. Spence, How to make an intestine, Development, 141, 752-760 (2014).
指導教授	陳宣毅(Hsuan-Yi Chen)	審核日期	2019-12-4
推文	facebook   plurk   twitter   funp   google   live   udn   HD   myshare   reddit   netvibes   friend   youpush   delicious   baidu
網路書籤	Google bookmarks   del.icio.us   hemidemi   myshare