利用不同造孔劑合成並分析具生物相容鈦鋯基金屬玻璃多孔醫用植入材

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阮帆泰(Van Tai Nguyen) 查詢紙本館藏

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機械工程學系

論文名稱

利用不同造孔劑合成並分析具生物相容鈦鋯基金屬玻璃多孔醫用植入材
(Synthesis and characterization of biocompatible TiZr-based bulk metallic glass foam using different space holders for bio-implant applications)

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摘要(中)

本次研究透過真空熱壓製程將無毒鈦鋯基金屬玻璃粉體以及造孔劑的混合物，成功製備一系列具生物相容性的多孔材，藉由調控氯化鈉以及鋁顆粒等兩種造孔劑的體積分率，設計出孔隙率介於2.0%到72.4%之間的熱壓鈦鋯基金屬玻璃多孔材。鈦鋯基金屬玻璃多孔材之形貌，其空孔孔徑落在75到300 m之間，與人體骨骼結構相似。首先，以X光繞射以及穿透式電子顯微鏡繞射進行分析，顯示鈦鋯基金屬玻璃粉體在經過熱壓製成多孔材之後依舊保持其非晶態。此外，我們可以成功藉由調整孔隙率達到調控楊氏系數的目的，當孔隙率從2.0%逐漸提高到72.4%時，鈦鋯基金屬玻璃多孔材的楊氏係數會從56.4 GPa降至2.3 GPa，抗壓強度從979 MPa降至19 MPa，彎曲強度從157 MPa降至49 MPa，使其更貼近人體骨骼。在生物相容性評估上，將2種造孔劑製備各孔隙率之鈦鋯金屬玻璃多孔材以並透過萃取法與直接接觸法進行細胞毒性和細胞外鈣沉積之測試，鈦鋯基金屬玻璃多孔材具備良好之生物相容性。使用萃取法測試孔隙率34.8％的多孔材在各稀釋溶液中，其細胞毒性和細胞外鈣沉積的平均細胞存活率和沈積率分別約為98.2％和224.4％。與此同時，使用直接接觸法測試孔隙率64.0％的多孔材在各稀釋溶液中，其細胞毒性和細胞外鈣沉積的平均細胞存活率和沈積率分別約為170.1％和130.9％。基於上述結果，鈦鋯基金屬玻璃多孔材應用在駐植物可藉由調控楊氏係數避免應力遮蔽效應，同時，優異的生物相容性表現可以視為生物植入材的明日之星。

摘要(英)

In this research, a series of biocompatible TiZr-based bulk metallic glass (BMG) foams (BMGFs) were successfully fabricated by hot pressing mixtures of toxic-element-free TiZr-based amorphous alloy powder and space holders. TiZr-based BMG samples with porosities ranging from 2.0% to 72.4% were designed by controlling the volume fractions of two space holders, namely NaCl and Al particles. The BMGFs fabricated using the aforementioned space holders exhibited pore sizes ranging from 75 to 300 m, which are similar to the pore sizes of human bones. X-ray diffraction patterns and transmission electron microscopy images revealed that the TiZr-based BMGFs remained the amorphous state after hot pressing. Moreover, when the porosity of the fabricated TiZr-based BMGFs was gradually increased from 2.0% to 72.4%, considerable reductions were observed in their Young’s modulus (from 56.4 to 2.3 GPa), compressive strength (from 979 to 19 MPa), and bending strength (from 157 to 49 MPa). The biocompatibility, namely noncytotoxicity and extracellular calcium deposition, of the TiZr-based BMGFs fabricated using NaCl and Al particles as the space holder was examined at various porosities by using the extract exposure and direct contact methods, respectively. The TiZr-based BMGFs exhibited high biocompatibility when both methods were performed. The BMGF with a porosity of 34.8%, which was tested in various diluted precipitate media by using the extract exposure method, exhibited an average cell survival of approximately 98.2% and a calcium deposition rate of approximately 224.4%. The BMGF with a porosity of 64.0%, which was tested using the direct contact method, exhibited an average cell survival rate of approximately 170.1% and a calcium deposition rate of approximately 130.9%. According to the aforementioned results, TiZr-based BMGFs have potential in bioimplants for the prevention of stress shielding and biounfriendly symptoms in the human body.

關鍵字(中)

★ 熱壓
★ 無定形材料
★ 生物材料
★ 機械性能
★ 多孔材料
★ 大塊金屬玻璃泡沫

關鍵字(英)

★ Hot-pressing
★ Amorphous materials
★ Biomaterials
★ Mechanical property
★ Porous materials
★ Bulk metallic glass foam

論文目次

摘要 i
Abstract ii
Acknowledgements iv
Contents v
List of Tables viii
List of Figures ix
Explanation of Symbols xiv
Chapter 1. INTRODUCTION 1
1-1 Development of TiZr-based Bulk Metallic Glass (BMG) 1
1-2 Challenges for TiZr-based BMGs 2
1-2-1 Glass-Forming Ability (GFA) 2
1-2-2 Biocompatibility 4
1-2-3 Mechanical Properties 5
1-3 Motivation and Goals 5
Chapter 2. LITERATURE REVIEWS 9
2-1 Characteristics of human bones 9
2-2 Designing Chemical Compositions of TiZr-based Bulk Metallic Glass (BMG) 11
2-3 Generating TiZr-based Metallic Glass (MG) powder 15
2-4 Fabricating TiZr-based Bulk Metallic Glass Foam (BMGF) 15
2-4-1 Space holder method 16
2-4-2 Replication method 17
2-4-3 Bubble generation 18
2-4-4 Freeze casting 20
2-4-5 Rapid prototyping 21
2-4-6 Conversion of porous ceramic precursor to metallic Ti foam 23
Chapter 3. EXPERIMENTAL DETAILS 25
3-1 Materials 25
3-1-1 Apparatus and Chemicals 25
3-1-2 Instrument 26
3-2 Experimental methods 28
3-2-1 Sample fabrication 28
3-2-2 Thermal stability analysis 30
3-2-3 Real Porosity 30
3-2-4 Microstructure characterization 31
3-2-5 Morphology 32
3-2-6 Mechanical property 32
3-2-7 Biocompatibility Tests 33
Chapter 4. RESULTS AND DISCUSSION 37
4-1 Thermal stability 37
4-2 Effects of conditional parameters on fabricating TiZr-based BMGF 39
4-3 Space holder removal 41
4-4 Real porosity 43
4-5 Morphology of TiZr-based BMGF 44
4-6 Structural characterization 46
4-7 Mechanical property 48
4-7-1 Young’s modulus, compressive strength and bending strength of TiZr-based BMFs 48
4-7-2 Predicting Young’s modulus and compressive strength by Gibson and Ashby model 50
4-8 Biocompatibility in vitro electrochemical testing 52
4-8-1 Extract exposure method 52
4-8-2 Direct contact method 54
Chapter 5. CONCLUSIONS 56
REFERENCES 58
Tables 68
Figures 81

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指導教授

鄭憲清(Jason Jang Shian-Ching)

審核日期

2020-7-23

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