| 摘要(英) |
In this study, takes the Alzheimer′s disease as a starting point, because a abnormal flow of cerebrospinal fluid causes amyloid beta to cause Alzheimer′s disease, which causes tens of millions of elderly people around the world to become get sick, it is of great concern. Combining microfluidic technology with biomedical techno-logy, using Polydimethylsiloxane to make a model with lithography process to rolling over, polydimethylsiloxane itself for hydrophobic, through the different types of microchannel with surface modification, so that surface modification to achieve hydrophilic, can improve the protein aggregat-ion effect by physical adsorption. Throu-gh the flow of artificial flow rate binding A-beta, use the instrument to detect and observe the surface condition, found that the surface modification of the surface to make A-beta inhibitors and A-beta protein have a joint effect, and improve the amyloid beta leave on the micro-channel, analyze the effects of different microchannel on aggregation.
In addition, the surface modification method integrate the microfluidic sys-tem to improve the functional group reaction. This study mainly analyzes the adsorption difference between column and smooth microchannel, because the surface area of the column is reduced, and the contact area increases, that A- beta protein contacts is enhanced, it can be more adsorbed inside the micro-channel. |
| 參考文獻 |
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