提高熔融沉積成型技術列印 PEEK試片之 親水性研究

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姓名

陳宥叡(Yu-Jui Chen) 查詢紙本館藏

畢業系所

機械工程學系

論文名稱

提高熔融沉積成型技術列印 PEEK試片之親水性研究
(Research on Improving the Hydrophilicity of PEEK Specimen Printed by Fused Deposition Molding Technology)

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★ 組織工程用冷凍成型積層製造之固態水支撐結構生成研究	★ 聚醚醚酮之積層製造系統開發

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至系統瀏覽論文 (2026-12-31以後開放)

摘要(中)

聚醚醚酮(Polyetheretherketone, PEEK)屬於熱塑性高分子聚合物，因此其特性非常適合作為積層製造技術的材料，且PEEK也在近幾年來非常頻繁的被運用在生物醫療方面的領域，尤其是人體植入物，由於其具備良好的生物相容性與機械強度，且PEEK與金屬植入物相較之下其彈性模數較接近人體皮質骨，且PEEK具備射線可穿透性並不會產生偽影，這在醫療方面相當重要，若產生偽影可能會造成術後的追蹤與診斷發生困難，也因此PEEK近年來在人體植入物這部分成為金屬替代材料的熱門選擇，但PEEK也存在一個相當大的缺陷，由於PEEK屬於生物惰性，因此造成PEEK在植入人體後其骨分化、細胞的附著與增殖的效果均不太良好，因此需要透過表面改質來增加其生物活性，本研究開發出了一種表面改質的方法，成功利用熔融沉積成型系統列印PEEK試片使其表面覆蓋一層聚乳酸-羥基磷灰石(PLA-HA)材料，隨後透過二氯甲烷溶解大部分的PLA材料，讓PEEK試片表面僅留下HA粉末與少量的PLA。

摘要(英)

Polyetheretherketone is a thermoplastic polymer, so its characteristics are very suitable as a material for multilayer manufacturing technology. In recent years, PEEK has also been frequently used in the field of biomedicine, especially human implants. Because of its good biocompatibility and mechanical properties, PEEK’s elastic modulus is closer to human cortical bone than metal implants. PEEK is radiolucent and does not produce artifacts. That is important to medical treatment, if artifacts are generated, it may be difficult to track and diagnose after surgery. Therefore, PEEK has become a popular choice to replace metal materials in human implants in recent years. However, PEEK also has a considerable defect. PEEK is biologically inert, so the effects of PEEK′s bone differentiation, cell adhesion and proliferation after implantation in the human body are not very good. Therefore, the surface modification is needed to increase its biological activity. This research has developed a surface modification method. The FDM system was successfully used to print the PEEK specimen to cover its surface with a layer of PLA-HA material, and then dissolve most of the PLA material through methylene chloride, leaving only HA powder and a small amount of PLA on the surface of the PEEK specimen.

關鍵字(中)

★ 聚醚醚酮
★ 積層製造技術
★ 熔融沉積成型
★ 親水性
★ 表面改質
★ 羥基磷灰石

關鍵字(英)

論文目次

摘要 I
ABSTRACT II
誌謝 III
目錄 IV
圖目錄 VI
表目錄 X
第一章緒論 1
1-1前言 1
1-2 文獻回顧 2
1-3 研究動機與目的 8
1-4 論文架構 9
第二章理論說明 10
2-1 聚醚醚酮之材料性質 10
2-2 聚醚醚酮之積層製造系統 13
2-3 聚醚醚酮之表面改質 21
2-4 聚乳酸之材料性質與應用 24
2-5 親水性測試 26
第三章研究方法 27
3-1 多噴頭積層製造系統架設 28
3-2 線材擠出機架設 42
3-3 羥基磷灰石-聚乳酸之複合FDM線材製備 45
3-4 試片製作流程 48
3-5 試片沉積策略之規劃 52
第四章實驗結果與討論 56
4-1 多噴頭FDM系統擠出線寬分析與PLA-HA線材成果 56
4-2 列印參數結果分析 60
4-3 沉積路徑與表面型態結果分析 65
4-4 試片親水性結果 71
第五章結論與未來展望 74
5-1 結論 74
5-2 未來展望 74
參考文獻 76

參考文獻

[1] C. Zhang, L. Wang, J. F. Kang, O. M. Fuentes and D. C. Li, "Bionic Design and Verification of 3D Printed PEEK Costal Cartilage Prosthesis", Journal of the Mechanical Behavior of Biomedical Materials, Vol. 103, 103561, 2020.
[2] X. B. Feng, L. Ma, H. Liang, X. M. Liu, J. Lei, W. Q. Li, K. Wang, Y. Song, B. J. Wang, G. C. Li, S. Li and C. Yang, "Osteointegration of 3D-Printed Fully Porous Polyetheretherketone Scaffolds with Different Pore Sizes", ACS Omega, Vol. 5, pp. 26655-26666, 2020.
[3] R. Ma, S. C. Tang, H. L. Tan, W. T. Lin, Y. G. Wang, J. Wei, L. M. Zhao and T. T. Tang, "Preparation, Characterization, and in Vitro Osteoblast Functions of A Nano-Hydroxyapatite/Polyetheretherketone Biocomposite as Orthopedic Implant Material", International Journal of Nanomedicine, Vol. 18, pp. 3949-3961, 2014.
[4] E. A. Wakelin, A. Fathi, M. Kracica, G. C. Yeo, S. G. Wise, A. S. Weiss, D. G. McCulloch, F. Dehghani, D. R. Mckenzie and M. M. M. Bilek, "Mechanical Properties of Plasma Immersion Ion Implanted PEEK for Bioactivation of Medical Devices", ACS Applied Materials & Interfaces, Vol. 7, pp. 23029-23040, 2015.
[5] Y. C. Zhu, Z. Cao, Y. Peng, L. Q. Hu, T. Guney and B. Tang, "Facile Surface Modification Method for Synergistically Enhancing the Biocompatibility and Bioactivity of Poly(ether ether ketone) That Induced Osteodifferentiation", ACS Applied Materials & Interfaces, Vol. 11, pp. 27503-27511, 2019.
[6] J. Khoury, I. Selezneva, S. Pestov, V. Tarassov, A. Ermakov, A. Mikheev, M. Lazov, S. R. Kirkpatrick, D. Shashkov and A. Smolkov, "Surface Bioactivation of PEEK by Neutral Atom Beam Technology", Bioactive Materials, Vol. 4, pp.132-141, 2019.
[7] C. C. Liu, J. F. Bai, Y. Wang, L. Chen, D. F. Wang, S. L. Ni and H. Liu, "The Effects of Three Cold Plasma Treatments on Theosteogenic Activity and Antibacterial Property of PEEK", Dental Materials, Vol. 37, pp.81-93, 2020.
[8] S. M. Kurtz, "Chapter 1 - An Overview of PEEK Biomaterials", PEEK Biomaterials Handbook, Oxford: William Andrew Publishing, pp. 1-7, 2012.
[9] H. B. Skinner, "Composite Technology for Total Hip Arthroplasty", Clinical Orthopaedics and Related Research, Vol 235, pp. 224-236, 1988.
[10] M. Bottlang, D. C. Fitzpatrick and P. Augat, "Musculoskeletal Biomechanics", Orthopaedic Knowledge Update, pp. 59-72, 2011.
[11] N. Sharma, S. Aghlmandi, S. S. Cao, C. Kunz, P. Honigmann and F. M. Thieringer, "Quality Characteristics and Clinical Relevance of In-House 3D-Printed Customized Polyetheretherketone (PEEK) Implants for Craniofacial Reconstruction", Journal of Clinical Medicine, Vol. 9, 2818, 2020.
[12] Invibio： News / Featured News, Available at ：https://invibio.com/global/press-releases/2021/first-peek-knee
[13] 吳柏論，「利用熔融沉積成型技術列印聚醚醚酮模型之機械性質改善與表面改質研究」，碩士論文，國立中央大學，民國108年。
[14] 黃俊瑋，「聚醚醚酮之積層製造系統開發」，碩士論文，國立中央大學，，民國105年。
[15] ApiumTEC：Products / Apium P220 , Available at ：https://apiumtec.com/en/industrial-3d-printer
[16] ApiumTEC：Products / Apium M220 , Available at ：https://apiumtec.com/en/industrial-3d-printer
[17] Intamsys：3D Printers / Funmat Pro 610 HT , Available at ：https://www.intamsys.com/funmat-pro-610-ht-3d-printer/
[18] Mosaic：Element / Element HT , Available at ：https://www.mosaicmfg.com/products/element-ht
[19] R. Ma and T. Tang, "Current Strategies to Improve the Bioactivity of PEEK", International Journal of Molecular Sciences, Vol. 15, pp. 5426-5445, 2014.
[20] D. Briem, S. Strametz, K. Schröoder, N. Meenen, W. Lehmann and W. Linhart, "Response of Primary Fibroblasts and Osteoblasts to Plasma Treated Polyetheretherketone (PEEK) Surfaces", Journal of Materials Science: Materials in Medicine, Vol. 16, pp. 671-677, 2005.
[21] W. June, An Introduction To Bioceramics, World Scientific, Vol. 1, 1993.
[22] C. C. Berndt, M. F. Hasan, U. Tietz and K.-P. Schmitz, "A Review of Hydroxyapatite Coatings Manufactured by Thermal Spray", Advances in Calcium Phosphate Biomaterials, pp. 267-329, 2014.
[23] Y. K. Yeon, H. S. Park, J. M. Lee, J. S. Lee, Y. J. Lee, M. T. Sultan, Y. B. Seo, O. J. Lee, S. H. Kim and C. H. Park, "New Concept of 3D Printed Bone Clip (Polylactic Acid/Hydroxyapatite/Silk Composite) for Internal Fixation of Bone Fractures", Journal of Biomaterials Science, Polymer Edition, Vol. 29, pp.894-906, 2017.
[24] Filabot：Machines / EX2 Extruder / Filabot EX2 Extruder Setup , Available at ：https://www.filabot.com/collections/ex2-extruder/products/ex2-bundle
[25] Inkbird：Product / Smart Controller / PID Temperature Controller , Available at ：https://inkbird.com/collections/pid-temperature-controller/products/itc-100
[26] M. A. Bakar, M. Cheng, S. Tang, S. Yu, K. Liao and C. Tan, "Tensile Properties, Tension–Tension Fatigue and Biological Response of Polyetheretherketone–Hydroxyapatite Composites for Load-Bearing Orthopedic Implants", Biomaterials, Vol. 24, pp. 2245-2250, 2003.
[27] J. Russias, E. Saiz, R. K. Nalla, K. Gryn, R. O. Ritchie and A. P. Tomsia, "Fabrication, and Mechanical Properties of PLA/HA Composites: A Study of in Vitro Degradation", Materials Science and Engineering: C, Vol. 26, pp.1289-1295, 2006.
[28] X. T. Jiang, Q. Wang and P. D. Zhang, " Preparation of Porous Polylactide /Hydroxyapatite Composites and Their in Vitro Degradation", Chemical Research and Application, Vol. 23, 100029, 2011.

指導教授

廖昭仰

審核日期

2021-9-28

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