室溫下簡易製備卡拉膠凝膠的三維結構與 自發形成卡拉膠微凝膠

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姓名

張峻崴(Jun-Wei Chang) 查詢紙本館藏

畢業系所

化學工程與材料工程學系

論文名稱

室溫下簡易製備卡拉膠凝膠的三維結構與自發形成卡拉膠微凝膠
(Facile fabrication of 3D structure of carrageenan gel at room temperature and spontaneous formation of carrageenan microgels)

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至系統瀏覽論文 (2028-6-30以後開放)

摘要(中)

卡拉膠是一種常用於食品水凝膠和藥物載體的線性、帶電多醣類。在區分氫鍵和陽離子橋兩種交聯的機制後，這項研究提出了一種新穎且簡便的方法，可在室溫下輕易地獲得能形成膠囊和自立薄膜的卡拉膠水凝膠。首先，透過氫鍵的作用可以形成弱凝膠，然後通過引入陽離子橋將其轉化為強凝膠。因此，可以將弱凝膠作為可生物降解的3D打印材料，通過將其注入含有特定陽離子的支撐介質中來製造不同的3D結構。當卡拉膠的濃度較低時，凝膠無法形成。但在陽離子橋的作用下，微米級的微凝膠仍然可以自發形成，而透過純氫鍵無法自然形成微凝膠。卡拉膠微凝膠的分散液展現出降伏應力和黏彈特性。經過離心後，增濃後的分散液展現了自我修復能力，其可作為3D列印的支撐介質。

摘要(英)

Carrageenan is a linear, charged polysaccharide that is commonly used as food hydrocolloids and drug carriers. After differentiating the gelling mechanisms of hydrogen bond and cation-bridge, this study presents a novel and facile method for obtaining carrageenan hydrogel that can be easily shaped into capsules and free-standing films at room temperature. Initially, a weak gel based solely on hydrogen bonds is developed, which can subsequently be transformed into a strong gel by introducing cation bridges. Therefore, the weak gel can be served as biodegradable 3D printing ink for producing structures by injecting it into a supporting medium containing specific cations. When the carrageenan concentration is low, the bulk gel fails to form. However, the micron-sized microgel can still form spontaneously due to cation-bridges, rather than hydrogen bonds. The dispersion of carrageenan microgels shows both yield stress and viscoelasticity. Upon centrifugation, the concentrated dispersion displays self-healing ability and can serve as a supporting medium for 3D printing.

關鍵字(中)

★ 卡拉膠
★ 膠囊
★ 三維列印油墨
★ 支撐介質
★ 微凝膠
★ 陽離子橋

關鍵字(英)

★ carrageenan
★ capsule
★ 3D printing ink
★ supporting medium
★ microgels
★ cation-bridge

論文目次

摘要 i
Abstract ii
誌謝 iii
Table of contents v
List of Figures vii
Chapter 1 Introduction 1
Chapter 2 Experiment 4
2-1 Materials 4
2-2 Preparation of carrageenan weak gel (without specific cations) 4
2-3 Preparation of carrageenan microgels (with specific cations) 4
2-4 Preparation of carrageenan fluid gel (with specific cations) 4
2-5 Preparation of concentrated dispersion of carrageenan microgels (0.5 wt%) 5
2-6 Measurement of rheological properties 5
2-7 Observation of carrageenan microgels by optical microscope 5
2-8 Writing the carrageenan weak gel in a supporting medium containing 2.0 wt% KCl (3D printing ink) 6
2-9 Writing in the concentrated dispersion of carrageenan microgels (supporting medium for 3D printing) 6
Chapter 3 Results and Discussion 7
3-1 Bulk gel formation by hydrogen bonds (without specific cations) 7
3-2 Gel formation by cation-bridge (with specific cations) 11
3-3 Dispersion of microgels 14
3-4 Self-healing property and 3D printing applications 20
Chapter 4 Conclusion 23
Reference 25

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指導教授

曹恆光(Heng-Kwong Tsao)

審核日期

2023-6-12

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