1,5-二氨基蒽醌與左氧氟沙星 於超臨界二氧化碳中之溶解度量測

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姓名

王煦宸(Hsu-Chen Wang) 查詢紙本館藏

畢業系所

化學工程與材料工程學系

論文名稱

1,5-二氨基蒽醌與左氧氟沙星於超臨界二氧化碳中之溶解度量測
(Measurement and Correlation of 1,5-Diaminoanthraquinone and Levofloxacin Solubility in Supercritical Carbon Dioxide)

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至系統瀏覽論文 (2033-6-30以後開放)

摘要(中)

本研究利用一組半流動式實驗裝置，測量1,5-二氨基蒽醌與左氧氟沙星於超臨界二氧化碳中之溶解度。其中，1,5-二氨基蒽醌量測條件為溫度353.2 K、373.2 K、 393.2 K壓力從17 MPa到27 MPa，而左氧氟沙星的量測條件則為溫度313.2 K、 323.2 K、333.2 K壓力從12 MPa到24 MPa。每個條件下的量測均進行了三次獨立實驗，確保其實驗結果的再現性，並取其平均值為該條件之結果。並且，為確保每次取樣的溶解度均為飽和溶解度，實驗首先進行了取樣流量測試，確認兩種溶質各自的取樣流量範圍。經實驗結果得知，1,5-二氨基蒽醌的取樣流量範圍為4~24 L/h，而左氧氟沙星的取樣流量範圍則為1.8~9 L/h。
本次量測的1,5-二氨基蒽醌與左氧氟沙星於超臨界二氧化碳中之莫耳分率介於9.81×10-7~1.29×10-6和1.34×10-7~2.71×10-6之間，兩者實驗數據之變異係數均小於4%。取得實驗數據後，本研究使用四種半經驗式模型: Chrastil模型、Mendez-Santiago and Teja（MST）模型、Kumar and Johnston（K-J）模型以及Bartle模型，對溶解度數據進行迴歸以及一致性檢測。其1,5-二氨基蒽醌與左氧氟沙星的迴歸結果之平均相對標準誤差(average absolute relative deviation)分別為4.97% (K-J)至7.44% (MST)與2.67% (MST)至12.73% (K-J)，並且皆在一致性檢測中皆呈現優良的線性關係，足以佐證本研究溶解度實驗數據量測的可靠度。

摘要(英)

In this study, the solubility of 1,5-Diaminoanthraquinone (C.I. DRII), and Levofloxacin in supercritical carbon dioxide was investigated. The solubility was measured by utilizing a semi-flow type apparatus. The measured conditions for C.I. DRII were at 353.2 K, 373.2K, and 393.2 K within a pressure range from 17 to 27 MPa, and for Levofloxacin were at 313.2 K, 323.2 K, and 333.2K. Three independent experiments were conducted for each condition to ensure the repeatability of the results. The average value was taken as the result of the condition. Additionally, a sampling flow rate test was applied to ensure that the solubility of each measurement was saturated. The results showed that the sampling flow rate of 1,5-diamino anthraquinone ranged from 4 to 24 L/h, while the sampling flow rate of levofloxacin ranged from 1.8 to 9 L/h.
In this study, the measured solubility of C.I. DRII and Levofloxacin in supercritical carbon dioxide was in the range of 9.81×10-8~1.29×10-7 and 1.34×10-7~2.71×10-6 in mole fraction. The coefficients of variation of both experimental data were less than 4%. Four semi-empirical models were then utilized for the correlation and the self-consistency tests, which were Chrastil model, Mendez-Santiago and Teja model (MST), Kumar and Johnston model (K-J). The average absolute relative deviations (AARD) for the correlation results were within 4.97% (K-J) ~7.44% (MST) for C.I. DRII, and 2.67% (MST)~12.73% (K-J) for Levofloxacin. Last but not least, the self-consistency tests were considered passed because almost all solubility data collapse into a single line, which indicated a good reliability of experimental measurements.

關鍵字(中)

★ 超臨界二氧化碳
★ 1,5-二氨基蒽醌
★ 溶解度
★ 左氧佛沙星

關鍵字(英)

★ ScCO2
★ Solubility
★ C.I. DRII
★ Levofloxacin

論文目次

摘要 i
Abstract ii
誌謝 iii
Table of contents iv
List of Figures vi
List of Tables viii
Chapter 1 Background 1
1-1 Introduction of Supercritical Fluid 1
1-2 Application of Supercritical Carbon Dioxide 5
1-3 Motivations 7
Chapter 2 Experimental 8
2-1 Experimental Materials 8
2-2 Experimental Device 10
2-3 Experimental Procedure 15
2-4 Chemical Analysis and Calibration Curve 18
Chapter 3 Data Correlation and Quality Assessments 22
3-1 Date Processing and Solubility Calculation 22
3-2 Data Correlation 29
3-3 Semi-empirical Models 30
(1) Chrastil model 35 30
(2) Méndez-Santiago and Teja model (MST model) 36 31
(3) Kumar and Johnston model (K-J model) 37 31
(4) Bartle model 38 31
3-4 Self-Consistency Test 33
Chapter 4 Result and Discussion 34
4-1 Reliability Test 34
4-2 The Effect of CO2 Flow Rates 35
4-3 Solubility of Solid Solutes in Supercritical Carbon Dioxide 37
4-4 Data Correlation 43
4-5 Self-Consistency Tests 50
Chapter 5 Conclusion 55
Reference 56

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指導教授

謝介銘(Chieh-Ming Hsieh)

審核日期

2023-7-24

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