脂質奈米顆粒在mRNA疫苗技術應用發展綜述

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姓名	葉咨甫(YEH TZU FU) 查詢紙本館藏	畢業系所	跨領域轉譯醫學研究所
論文名稱	脂質奈米顆粒在mRNA疫苗技術應用發展綜述 (A review of technological developments in lipid nanoparticle application for mRNA vaccination)
檔案	[Endnote RIS 格式] [Bibtex 格式] [相關文章] [文章引用] [完整記錄] [館藏目錄] 至系統瀏覽論文 (2026-1-24以後開放)
摘要(中)	本研究深入探討了脂質納米粒子（LNP）技術在mRNA領域的專利格局，並分析了其在生物醫學領域的技術創新。研究旨在揭示技術創新是否遵循技術線性模型，同時深入研究核心技術團隊、關鍵專利以及相關疫苗專利的發展。過往研究對於LNP技術和mRNA疫苗的專利格局及專利糾紛關注不足，本研究填補了這一空白。我們透過文獻引用分析、專利分析、專利訴訟案例研究等多元方法，詳細梳理了LNP技術的專利現狀，並探討了專利叢林對技術創新的影響及專利豁免政策的實際效果。本研究發現，LNP技術在mRNA疫苗開發中發揮了關鍵作用，其創新過程符合技術線性模型。研究還指出，專利格局及市場競爭格局中，賓州大學和麻省理工學院等學術機構在基礎研究上作出了顯著貢獻，而Moderna、BioNTech等公司在專利申請和市場競爭中佔有重要地位。此外，專利叢林現象和專利訴訟案例顯示，專利權的行使可能對技術創新和公共衛生利益產生重大影響。綜上所述，本研究不僅深入分析了LNP技術在mRNA領域的專利狀況，還探討了專利政策對技術創新和公共衛生的複雜影響，為相關利益者提供了寶貴的見解和策略建議，有助於促進技術創新並維護公共利益。
摘要(英)	This study delves into the patent landscape of Lipid Nanoparticle (LNP) technology in the mRNA field and analyzes its technological innovation in the biomedical domain. It aims to reveal whether technological innovation follows the linear model of technology and examines in-depth the core technical teams, key patents, and the development of related vaccine patents.Previous research has inadequately focused on the patent landscape and disputes concerning LNP technology and mRNA vaccines. This study fills this gap. Employing diverse methodologies such as literature citation analysis, patent analysis, and case studies of patent litigation, we comprehensively outline the current patent status of LNP technology and discuss the impact of patent thickets on technological innovation, along with the practical effects of patent exemption policies. Our findings indicate that LNP technology plays a pivotal role in the development of mRNA vaccines, aligning with the linear model of technology innovation. The study also identifies significant contributions of academic institutions such as the University of Pennsylvania and MIT in basic research, while companies like Moderna and BioNTech hold significant positions in patent applications and market competition. Furthermore, phenomena like patent thickets and cases of patent litigation suggest that the exercise of patent rights can significantly impact technological innovation and public health interests. In summary, this research not only analyzes in depth the patent status of LNP technology in the mRNA field but also explores the complex impact of patent policies on technological innovation and public health. It provides valuable insights and strategic recommendations for stakeholders, aiding in the promotion of technological innovation and the safeguarding of public interests.
關鍵字(中)	★ 脂質奈米顆粒 ★ mRNA 疫苗 ★ COVID-19 ★ 期刊分析 ★ 專利分析 ★ 生物醫藥專利	關鍵字(英)	★ Lipid Nanoparticle (LNP) ★ mRNA vaccine ★ COVID-19 ★ journal analysis ★ patent analysis ★ biomedical patents
論文目次	目錄中文摘要 ·································································································vii 英文摘要 ································································································viii 致謝 ········································································································ix 目錄 ·········································································································x 圖目錄 ···································································································xiii 表目錄 ···································································································xiv 一、緒論： ················································································- 1 - 1-1 研究動機 ·············································································- 1 - 1-2 本研究之貢獻 ·······································································- 2 - 1-3 章節介紹 ·············································································- 3 - 二、文獻回顧 ·············································································- 5 - 2-1 全球新冠疫情的挑戰與 mRNA 疫苗的崛起 ··································- 5 - 2-2 mRNA 疫苗在 COVID-19 中的關鍵作用 ······································- 7 - 2-3 mRNA 疫苗與 LNP 技術的發展歷程 ··········································- 10 - 2-3-1 mRNA 疫苗介紹 ···································································- 10 - 2-3-2 LNP 遞送技術發展與在 mRNA 疫苗中的重要性 ···························- 12 - 2-4 專利制度與生物醫學創新 ·······················································- 14 - 2-4-2 生物醫藥專利的發展背景 ·······················································- 15 - 2-4-3 創新線性模型 ······································································- 16 - 2-5 專利叢林與創新障礙 ·····························································- 18 - 2-5-2 反公地悲劇理論 ···································································- 19 - 2-5-3 專利叢林理論 ······································································- 19 - 2-5-4 關於生醫專利阻礙創新的實證研究 ···········································- 20 - 2-6 疫苗專利與公共衛生的衝突 ····················································- 21 - 2-7 小結 ··················································································- 23 - 三、創新線性理論研究及分析 ·······················································- 24 - 3-1 研究問題與研究方法 ·····························································- 24 - 3-2 研究方法 ············································································- 25 - 3-3 mRNA 疫苗與 LNP 技術發展概況 ·············································- 25 - 3-4 mRNA 與 LNP 技術的期刊與專利引用分析 ·································- 29 - 3-4-1 31 篇文章與專利引用關係·······················································- 29 - 3-4-2 21 件 mRNA 疫苗與 LNP 專利與文章引用關係·····························- 35 - 3-4-3 期刊作者與專利發明人的分析 ·················································- 40 - 3-5 小結 ··················································································- 45 - 四、 mRNA 與 LNP 技術領域的核心研發團隊 ····································- 46 - 4-1 關於 mRNA 和 LNP 專利研究文獻回顧 ······································- 46 - 4-2 研究方法 ············································································- 48 - 4-2-1 期刊資料庫 ·········································································- 48 - 4-2-2 專利資料庫 ·········································································- 49 - 4-2-3 選擇兩個資料庫之理由 ··························································- 49 - 4-2-4 檢索策略 ············································································- 50 - 4-3 核心研究團隊分析 ································································- 52 - 4-3-1 趨勢分析 ············································································- 52 - 4-3-2 期刊分析 ············································································- 56 - 4-3-3 專利分析 ············································································- 60 - 4-3-4 期刊與專利的相關性分析 ·······················································- 64 - 4-3-5 高引用的期刊分析 ································································- 69 - 4-4 小結 ··················································································- 71 - 五、 mRNA 與 LNP 技術的專利訴訟分析 ··········································- 73 - 5-1 前言 ··················································································- 73 - 5-2 mRNA 與 LNP 技術的專利訴訟分析 ··········································- 74 - 5-3 研究議題 ············································································- 83 - 5-3-1 八家領先企業的專利格局 ·······················································- 83 - 5-4 核心專利評估 ······································································- 92 - 5-4-1 參與訴訟專利評估 ································································- 93 - 5-4-2 專利引用和同族專利的評估 ····················································- 95 - 5-4-3 研究報告中的關鍵專利 ··························································- 98 - 5-4-4 LNP 專利格局分析 ································································- 99 - 5-5 小結 ················································································- 103 - 六、疫苗專利對技術創新的案例分析 ············································- 104 - 6-1 疫苗專利阻礙技術創新的研究 ···············································- 104 - 6-2 專利豁免案例研究 ······························································- 106 - 6-2-1 支持與反對專利豁免的立場 ··················································- 106 - 6-2-2 COVID-19 期間的自願授權 ···················································- 109 - 6-2-3 專利豁免政策對於疫苗生產商的影響 ······································- 113 - 6-3 小結 ················································································- 115 - 七、綜合討論 ··········································································- 117 - 7-1 創新線性模型是否適用於 LNP 技術在 mRNA 領域？ ··················- 117 - 7-2 當前 LNP 技術在 mRNA 領域的專利與市場競爭格局？ ···············- 118 - 7-3 LNP 技術在 mRNA 領域是否存在阻礙技術創新或限制疫苗流通？ ·- 119 - 7-4 小結 ················································································- 121 - 八、結論： ·············································································- 123 - 參考文獻 ····························································································- 125 - 附件 1 八家核心企業核心專利································································- 146 -
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指導教授	林澂宋皇志(Chen Lin Huang-Chih Sung)	審核日期	2024-1-29
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