熱誘導混合聚丙烯薄膜含雙離子共聚物的製備研究及其抗污性能的探討

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姓名	陳胤霖(Yin-Lin Chen) 查詢紙本館藏	畢業系所	化學工程與材料工程學系
論文名稱	熱誘導混合聚丙烯薄膜含雙離子共聚物的製備研究及其抗污性能的探討 (Study on the preparation of thermal-induced blended polypropylene films containing zwitterionic copolymers and investigation of their anti-fouling properties)
檔案	[Endnote RIS 格式] [Bibtex 格式] [相關文章] [文章引用] [完整記錄] [館藏目錄] 至系統瀏覽論文 (2029-9-1以後開放)
摘要(中)	隨著科技的發展和進步，人們對健康的意識也增強了，伴隨著醫療設備的迅速進步。在其中，帶有雙離子結構的系統因其出色的生物相容性而被廣泛研究和應用，這是生物惰性材料的關鍵。此外，在過去，製備生物防污膜需要使用有機溶劑，這會導致環境污染，加上政府倡導與綠色過程相關的政策。因此，本研究採用無溶劑膜處理方法。通過自由基聚合反應合成了三種不同比例的苯乙烯-馬來酸酐共聚物（Styrene-co-Maleic Anhydride, SMA），分別命名為S25MA25、S50MA50和S70MA30。隨後，通過兩種不同的方法將SMA共聚物與聚丙烯（PP）物理混合，並加入雙螺桿微複合機，在雙螺桿的剪切力下將SMA和PP均勻混合，然後使用熱壓成膜。此外，合成了含有胺端的雙離子單體磺化3-二甲胺丙胺（DMAPAPS），並溶解於甲醇中製備修飾溶液，然後用於浸漬膜進行開環反應以獲得表面雙離子膜。本研究對SMA共聚物進行物化分析，接著檢測雙離子單體的物化性質，以及薄膜表面改質的物理與化學性質分析，最後對混摻膜進行生物惰性檢測，在相對於PS標準片的結果顯示下，於直接混練法中，發現添加共聚物濃度條件為10 PHR的薄膜具有95.33%的抗沾黏能力；而在表面塗層混練法中，發現添加S50MA50共聚物之薄膜具有89.57%的抗沾黏能力。
摘要(英)	With the development and advancement of technology, people′s awareness of health has increased, accompanied by rapid progress in medical equipment. Among these advancements, systems with zwitterionic structures have been extensively researched and applied due to their excellent biocompatibility, which is crucial for bioinert materials. In the past, the preparation of biofouling-resistant membranes required the use of organic solvents, leading to environmental pollution. In addition, government policies advocate for processes related to green initiatives. Therefore, this study adopts a solvent-free membrane treatment method. Through free radical polymerization, three different ratios of Styrene-co-Maleic Anhydride (SMA) copolymers were synthesized, named S25MA25, S50MA50, and S70MA30, respectively. Subsequently, the SMA copolymers were physically mixed with polypropylene (PP) using two different methods, and then uniformly mixed under the shearing force of a twin-screw extruder, followed by hot pressing to form membranes. Additionally, a zwitterionic monomer with an amine end, sulfobetaine 3-dimethylaminopropylamine (DMAPAPS), was synthesized and dissolved in methanol to prepare a modification solution, which was then used to dip the membranes for a ring-opening reaction to obtain surface zwitterionic membranes. This study conducted physicochemical analyses of the SMA copolymers, followed by testing the zwitterionic monomer′s physicochemical properties and analyzing the surface-modified membranes′ physical and chemical properties. Finally, bioinertness tests were performed on the blended membranes. Compared to the PS standard film results, it was found that in the direct blending method, the membranes with a copolymer concentration of 10 PHR exhibited 95.33% anti-fouling ability; in the surface coating blending method, the membranes with the addition of the S50MA50 copolymer exhibited 89.57% anti-fouling ability.
關鍵字(中)	★ 苯乙烯-馬來酸酐共聚物 ★ 雙離子材料 ★ 雙螺桿微型混鍊機 ★ 無溶劑薄膜製程	關鍵字(英)	★ Styrene-Maleic Anhydride Copolymer ★ Zwitterionic ★ Twin-Screw Microcompounder ★ Solvent-Free Membrane Fabrication Process
論文目次	摘要 i Abstract ii 誌謝 iii 目錄 iv 圖目錄 vii 表目錄 x 化學品名詞代稱 xi 產物名詞代稱 xii 一、文獻回顧 1 1-1 生醫材料 1 1-1-1 生醫材料介紹 1 1-1-2 生醫材料的種類 3 1-2 生物惰性材料 5 1-2-1 生物惰性材料發展歷程 5 1-2-2 雙離子系統 8 1-3 薄膜改質技術 10 1-3-1 薄膜高分子設計 10 1-3-2 薄膜表面改質方法 12 1-4 熔融混練技術 14 1-4-1 微型混練機介紹 14 1-4-2 螺桿旋轉方向的影響 17 1-5 馬來酸酐類材料 18 1-5-1 馬來酸酐介紹 18 1-5-2 聚(苯乙烯-馬來酸酐)共聚物 21 二、研究目的 22 三、實驗藥品、儀器與實驗方法 23 3-1 實驗藥品 23 3-1-1 一般藥品 23 3-1-2 菌種培養 30 3-2 實驗設備與儀器 31 3-2-1 實驗設備 31 3-2-2 實驗儀器 33 3-3 實驗材料製備 34 3-3-1 共聚物合成方法 34 3-3-2 雙離子單體製備方法 36 3-3-3 熱混合聚丙烯薄膜製備方法 37 3-3-4 薄膜表面改質方法 39 3-4 實驗方法 40 3-4-1 共聚物鑑定與檢測 40 3-4-2 雙離子單體鑑定與檢測 42 3-4-3 薄膜物化性質檢測 43 3-4-4 細菌貼附測試 46 四、實驗結果與討論 48 4-1 共聚物合成結果鑑定 48 4-1-1 共聚物定量分析 48 4-1-2共聚物定性分析 52 4-1-3 熱穩定性檢測 53 4-2 雙離子單體合成結果鑑定 55 4-2-1 雙離子單體定量分析 55 4-2-2 雙離子單體定性分析 57 4-3 薄膜形貌 58 4-3-1 直接混練法（系統一） 58 4-3-2 表面塗層混練法（系統二） 60 4-4 改質膜表面物理化學分析 61 4-4-1 薄膜表面親水性 61 4-4-2 薄膜表面元素分析 63 4-4-3 薄膜表面粗糙度 69 4-5 薄膜生物惰性測試 72 4-5-1 直接混練法（系統一） 72 4-5-1 表面塗層混練法（系統二） 74 五、結論 76 六、參考文獻 77
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指導教授	黃俊仁張雍(Chun-Jen Huang Yung Chang)	審核日期	2024-8-20
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