摘要(英) |
In clinical studies and biomedical research, it is common to encounter continuous
bounded data, such as body fat percentage. This paper focuses on a dataset that
includes body fat percentages measured at five regions of each body: arms, legs,
trunk, android, and gynoid. Since these five observations come from the same
individual, correlations exist in different responses. Some researchers choose
multivariate generalized linear mixed models (MGLMMs) to model this type of data.
However, when dealing with high-dimensional data, estimating the maximum
likelihood often faces challenges due to high-dimensional integration. Furthermore, if
the model is misspecified, the analysis may yield incorrect results.
This paper applies a robust multivariate negative binomial likelihood function to
analyze multivariate continuous bounded data. In addition to consistent estimates for
the parameters of interest, the adjusted likelihood function enables obtaining correct
asymptotic variance estimates. Moreover, the robust Wald statistics, robust score
statistics, and robust likelihood ratio statistics presented in this paper show that the
robust likelihood approach can always make correct statistical inferences even if the
true underlying distribution is unknown |
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http://leg.ufpr.br/doku.php/publications:papercompanions:mglmmbound
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