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| 題名: | Association between air pollutants and dementia risk in the elderly |
| 作者: | 林遠見;Wu, Yun-Chun;Lin, Yuan-Chien;Yu, Hwa-Lung;Chen, Jen-Hau;Chen, Ta-Fu;Sun, Yu;Wen, Li-Li;Yip, Ping-Keung;Chu, Yi-Min;Chen, Yen-Ching |
| 貢獻者: | 工學院土木工程學系 |
| 關鍵詞: | Advertising executives;Air pollutant;Air pollution;Alzheimer's disease;Apolipoproteins;Neurology;Other;Ozone;Particulate matter;Pollutants;Risk factors;Special Invited : Environmental Toxicology;Surveys;The elderly;Type 2 diabetes;Vascular dementia |
| 日期: | 2015-01-01 |
| 上傳時間: | 2026-04-21 13:50:10 (UTC+8) |
| 出版者: | Elsevier BV;United States: John Wiley & Sons, Inc |
| 摘要: | 摘要： Abstract Background The aging rate in Taiwan is the second highest in the world. As the population ages quickly, the prevalence of dementia increases rapidly. There are some studies that have explored the association between air pollution and cognitive decline, but the association between air pollution and dementia has not been directly evaluated. Methods This was a case-control study comprising 249 Alzheimer's disease (AD) patients, 125 vascular dementia (VaD) patients, and 497 controls from three teaching hospitals in northern Taiwan from 2007 to 2010. Data of particulate matter <10 μm in diameter (PM10 ) and ozone were obtained from the Taiwan Environmental Protection Administration for 12 and 14 years, respectively. Blood samples were collected to determine the apolipoprotein E ( APOE ) ɛ4 haplotype. Bayesian maximum entropy was used to estimate the individual exposure level of air pollutants, which was then tertiled for analysis. Conditional logistic regression models were used to estimate adjusted odds ratios (AORs) and 95% confidence intervals between the association of PM10 and ozone exposure with AD and VaD risk. Results The highest tertile of PM10 (≥49.23 μg/m3 ) or ozone (≥21.56 ppb) exposure was associated with increased AD risk (highest vs. lowest tertile of PM10 : AOR = 4.17; highest vs. lowest tertile of ozone: AOR = 2.00). Similar finding was observed for VaD. The association with AD and VaD risk remained for the highest tertile PM10 exposure after stratification by APOE ɛ4 status and gender. Conclusions Long-term exposure to the highest tertile of PM10 or ozone was significantly associated with an increased risk of AD and VaD.
其他題名： Alzheimers Dement (Amst)
出版者： United States: John Wiley & Sons, Inc
出版日期： 2015-06
出處： Alzheimer's & dementia : diagnosis, assessment & disease monitoring, 2015-06, Vol.1 (2), p.220-228
資源來源： [Open Access] DOAJ 오픈액세스 저널 디렉토리
版權： The Authors
版權： 2015 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.
版權： COPYRIGHT 2015 John Wiley & Sons, Inc.
版權： 2015 The Authors 2015
識別號： ISSN: 2352-8729
識別號： EISSN: 2352-8729
識別號： DOI: 10.1016/j.dadm.2014.11.015
識別號： PMID: 27239507 |
| 顯示於類別: | [土木工程學系 ] 期刊論文
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