Determination of perfluorochemicals in human milk using isotope-dilution liquid chromatography tandem mass spectrometry

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題名:	Determination of perfluorochemicals in human milk using isotope-dilution liquid chromatography tandem mass spectrometry
作者:	丁望賢;Wang, Yu-Chen;Lin, Angela Yu-Chen;Wang, Shu-Li;Ding, Wang-Hsien
貢獻者:	理學院化學學系
關鍵詞:	Human milk;Isotope dilution liquid chromatography tandem mass spectrometry;Perfluorochemicals;Solid-phase extraction
日期:	2012-04-01
上傳時間:	2026-04-21 13:55:09 (UTC+8)
出版者:	Wiley-Blackwell;Weinheim: WILEY-VCH Verlag
摘要:	摘要： A highly precise and accurate analytical method utilizing an isotope‐dilution liquid chromatography tandem mass spectrometry was developed and validated to determine two perfluorochemicals (PFCs): perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) in human milk samples. Identification of the analytes was confirmed under negative electrospray with multiple reaction monitoring (MRM) mode by the monitoring of one precursor ion and two product ions, and matching of relative ion intensities of the ions concerned in samples and calibration standards. Quantitation was based on the measurement of concentration ratios of the natural and labeled‐analogues in the samples and calibration mixtures. The isotope‐labeled internal standards were also used to correct the matrix effect and variations associated with the analysis. Intra‐ and inter‐day repeatabilities of replicate analyses of the PFOA and PFOS in milk samples were below 8%. The limit of quantitation was 2 pg/mL in a 5 mL milk sample. The PFOA and PFOS were detected in all 20 human milk samples at concentrations from 27.0 to 207 pg/mL. This is the first study to measure the occurrence of PFOA and PFOS in human milk from Taiwan. A highly precise and accurate analytical method utilizing an isotope‐dilution LC‐ESI‐MS/MS was developed and validated to determine perfluoro octanoate (PFOA) and perfluorooctanesulfonate (PFOS) in human milk samples. They were detected in all 20 human milk samples at concentrations from 27.0 to 207 pg/mL, and the median of concentrations were 74.4 and 62.4 pg/mL for PFOA and PFOS, respectively. 其他題名： Jnl Chinese Chemical Soc 出版者： Weinheim: WILEY-VCH Verlag 出版日期： 2012-04 出處： Journal of the Chinese Chemical Society (Taipei), 2012-04, Vol.59 (4), p.544-549 版權： Copyright © 2012 The Chemical Society Located in Taipei & Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim, Germany 識別號： ISSN: 0009-4536 識別號： EISSN: 2192-6549 識別號： DOI: 10.1002/jccs.201100528
顯示於類別:	[化學學系] 期刊論文

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