| Abstract: | 摘要： AbstractBackgroundParticulate air pollution is associated with increased risk of cardiovascular disease and stroke. Although the precise mechanisms underlying this association are still unclear, the induction of systemic inflammation following particle inhalation represents a plausible mechanistic pathway.MethodsWe used baseline data from the CoLaus Study including 6183 adult participants residing in Lausanne, Switzerland. We analyzed the association of short-term exposure to PM10 (on the day of examination visit) with continuous circulating serum levels of high-sensitive C-reactive protein (hs-CRP), interleukin 1-beta (IL-1β), interleukin 6 (IL-6), and tumor-necrosis-factor alpha (TNF-α) by robust linear regressions, controlling for potential confounding factors and assessing effect modification.ResultsIn adjusted analyses, for every 10 μg/m3 elevation in PM10, IL-1ß increased by 0.034 (95 % confidence interval, 0.007-0.060) pg/mL, IL-6 by 0.036 (0.015-0.057) pg/mL, and TNF-α by 0.024 (0.013-0.035) pg/mL, whereas no significant association was found with hs-CRP levels.ConclusionsShort-term exposure to PM10 was positively associated with higher levels of circulating IL-1ß, IL-6 and TNF-α in the adult general population. This positive association suggests a link between air pollution and cardiovascular risk, although further studies are needed to clarify the mechanistic pathway linking PM10 to cardiovascular risk.
其他題名： Part Fibre Toxicol
出版者： London: Springer Science and Business Media LLC
出版日期： 2012-07-06
出處： Particle and Fibre Toxicology, 2012-07, Vol.9 (1), p.1--24, Article 24
資源來源： Agricultural & Environmental Science Collection
版權： Tsai et al.; licensee BioMed Central Ltd. 2012 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
版權： COPYRIGHT 2012 BioMed Central Ltd.
版權： Copyright ©2012 Tsai et al.; licensee BioMed Central Ltd. 2012 Tsai et al.; licensee BioMed Central Ltd.
識別號： ISSN: 1743-8977
識別號： EISSN: 1743-8977
識別號： DOI: 10.1186/1743-8977-9-24
識別號： PMID: 22769230 |
