Continuous co-crystallization as a separation technology: The study of 1:2 co-crystals of phenazine-vanillin

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Title:	Continuous co-crystallization as a separation technology: The study of 1:2 co-crystals of phenazine-vanillin
Authors:	李弘霖;Lee, Tu;Chen, Hsin Rong;Lin, Hong Yu;Lee, Hung Lin
Contributors:	工學院化學工程與材料工程學系
Keywords:	Condensed matter: structure, mechanical and thermal properties;Cross-disciplinary physics: materials science;rheology;Equations of state, phase equilibria, and phase transitions;Exact sciences and technology;General studies of phase transitions;Materials science;Methods of crystal growth;physics of crystal growth;Nucleation;Physics;Solid-solid transitions;Specific phase transitions
Date:	2012-12-05
Issue Date:	2026-04-21 14:04:08 (UTC+8)
Publisher:	American Chemical Society;Washington,DC: American Chemical Society
Abstract:	摘要： The selective removal of vanillin in bioconversion by forming 1:2 co-crystals of phenazine–vanillin may serve as a new technology. Initial solvent screening experiments of vanillin, phenazine, and the co-crystals show that co-crystallization of phenazine and vanillin can be formed in toluene and, later, regenerated in acetone as Form α phenazine and vanillin solution. Co-crystallization is successfully carried out in both continuous and batch modes with no agitation and with stirring. However, it is found that the efficient heat transfer due to the instant drop of bulk solution temperature to 25 °C in continuous co-crystallization at 90 mL/min gives the advantages of a rapid nucleation rate, B 0, of 2.8 × 104 ± 4 × 103 no/l·s as determined by the mixed suspension, mixed product removal (MSMPR) formalism for the population balance, a wider and flatter size distribution of 18 wt % for particle sizes of >75 to >250 μm and about 12 wt % of >300 to >500 μm by sieve analysis, and a high yield of 51.2 ± 0.7 wt % in comparing with the ones of 34.9 ± 0.4 wt % from batch operation with no agitation and 57.7 ± 8.1 wt % from batch mode with stirring. The wider size distribution of particle sizes gives a better filterability of the wet cake and flowability of the dried co-crystals. 其他題名： Cryst. Growth Des 出版者： Washington,DC: American Chemical Society 出版日期： 2012-12-05 出處： Crystal growth & design, 2012-12, Vol.12 (12), p.5897-5907 資源來源： American Chemical Society Journals 版權： Copyright © 2012 American Chemical Society 版權： 2014 INIST-CNRS 識別號： ISSN: 1528-7483 識別號： EISSN: 1528-7505 識別號： DOI: 10.1021/cg300763t
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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