Hemocompatible control of sulfobetaine-grafted polypropylene fibrous membranes in human whole blood via plasma-induced surface zwitterionization

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Title:	Hemocompatible control of sulfobetaine-grafted polypropylene fibrous membranes in human whole blood via plasma-induced surface zwitterionization
Authors:	樋口亞紺;Chen, Sheng-Han;Chang, Yung;Lee, Kueir-Rarn;Wei, Ta-Chin;Higuchi, Akon;Ho, Feng-Ming;Tsou, Chia-Chun;Ho, Hsin-Tsung;Lai, Juin-Yih
Contributors:	工學院化學工程與材料工程學系
Keywords:	Adsorption;anticoagulants;Anticoagulants - chemistry;Anticoagulants - pharmacology;betaine;Betaine - analogs & derivatives;Betaine - chemistry;Biocompatible Materials - chemistry;Biocompatible Materials - pharmacology;blood platelets;Blood Proteins - chemistry;cell adhesion;Chemistry;Colloidal state and disperse state;enzyme-linked immunosorbent assay;Exact sciences and technology;fibrinogen;General and physical chemistry;Humans;hydrophilicity;Hydrophobic and Hydrophilic Interactions;hydrophobicity;Membranes;Membranes, Artificial;Methacrylates - chemistry;moieties;monoclonal antibodies;Plasma - chemistry;platelet activation;Platelet Adhesiveness - drug effects;polymerization;polypropylenes;Polypropylenes - chemistry;Surface physical chemistry;Surface Properties;zwitterions
Date:	2012-12-21
Issue Date:	2026-04-21 14:05:09 (UTC+8)
Publisher:	American Chemical Society;Washington, DC: American Chemical Society
Abstract:	摘要： In this work, the hemocompatibility of zwitterionic polypropylene (PP) fibrous membranes with varying grafting coverage of poly(sulfobetaine methacrylate) (PSBMA) via plasma-induced surface polymerization was studied. Charge neutrality of PSBMA-grafted layers on PP membrane surfaces was controlled by the low-pressure and atmospheric plasma treatment in this study. The effects of grafting composition, surface hydrophilicity, and hydration capability on blood compatibility of the membranes were determined. Protein adsorption onto the different PSBMA-grafted PP membranes from human fibrinogen solutions was measured by enzyme-linked immunosorbent assay (ELISA) with monoclonal antibodies. Blood platelet adhesion and plasma clotting time measurements from a recalcified platelet-rich plasma solution were used to determine if platelet activation depends on the charge bias of the grafted PSBMA layer. The charge bias of PSBMA layer deviated from the electrical balance of positively and negatively charged moieties can be well-controlled via atmospheric plasma-induced interfacial zwitterionization and was further tested with human whole blood. The optimized PSBMA surface graft layer in overall charge neutrality has a high hydration capability and keeps its original blood-inert property of antifouling, anticoagulant, and antithrmbogenic activities when it comes into contact with human blood. This work suggests that the hemocompatible nature of grafted PSBMA polymers by controlling grafting quality via atmospheric plasma treatment gives a great potential in the surface zwitterionization of hydrophobic membranes for use in human whole blood. 其他題名： Langmuir 出版者： Washington, DC: American Chemical Society 出版日期： 2012-12-21 出處： Langmuir, 2012-12, Vol.28 (51), p.17733-17742 資源來源： American Chemical Society Journals 版權： Copyright © 2012 American Chemical Society 版權： 2014 INIST-CNRS 識別號： ISSN: 0743-7463 識別號： ISSN: 1520-5827 識別號： EISSN: 1520-5827 識別號： DOI: 10.1021/la3036902 識別號： PMID: 23181727 識別號： CODEN: LANGD5
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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