Enantioselective additions of aryltitanium tris(isopropoxide) to ketones: Structure of [(i-PrO)2Ti{μ-(S)-BINOLate}(μ-O-i-Pr)TiPh(O-i-Pr) 2], study of mechanistic and stereochemical insights

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題名:	Enantioselective additions of aryltitanium tris(isopropoxide) to ketones: Structure of [(i-PrO)2Ti{μ-(S)-BINOLate}(μ-O-i-Pr)TiPh(O-i-Pr) 2], study of mechanistic and stereochemical insights
作者:	吳國暉;Wu, Kuo-Hui;Kuo, Yi-Yin;Chen, Chien-An;Huang, Yi-Ling;Gau, Han-Mou
貢獻者:	理學院化學學系
關鍵詞:	Aromatic compounds;aryl addition;aryltitaniums;enantioselectivity;ketones;titanium
日期:	2013-03-25
上傳時間:	2026-04-21 14:08:00 (UTC+8)
出版者:	Wiley-VCH Verlag;Weinheim: WILEY-VCH Verlag
摘要:	摘要： AbstractAryl addition reactions of ArTi(O‐i‐Pr)3 to aromatic, heteroaromatic, or α,β‐unsaturated ketones are described, producing tertiary alcohols in good to excellent enantioselectivities of up to 97% ee. The structure of the dititanium complex [(i‐PrO)2Ti{μ‐(S)‐BINOLate}(μ‐O‐i‐Pr)TiPh(O‐i‐Pr)2] [(S)‐4] that simultaneously bears a chiral directing ligand and a nucleophile is reported. Complex (S)‐4 possesses a pocket structure and has been illustrated as the key active species for addition reactions of both aldehydes and ketones. Mechanistic and stereochemical insights concerning addition reactions of organometallic reagents to organic carbonyls are rationalized based on the pocket structure and pocket size of (S)‐4. 其他題名： Adv. Synth. Catal 出版者： Weinheim: WILEY-VCH Verlag 出版日期： 2013-03-25 出處： Advanced Synthesis & Catalysis, 2013-03, Vol.355 (5), p.1001-1008 版權： Copyright © 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim 識別號： ISSN: 1615-4150 識別號： EISSN: 1615-4169 識別號： DOI: 10.1002/adsc.201200672
顯示於類別:	[化學學系] 期刊論文

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