Coelectrospinning of chitosan/alginate fibers by dual-jet system for modulating material surfaces

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Title:	Coelectrospinning of chitosan/alginate fibers by dual-jet system for modulating material surfaces
Authors:	胡威文;Hu, Wei-Wen;Yu, Hsing-Ning
Contributors:	工學院化學工程與材料工程學系
Keywords:	Alginate;Alginates - chemistry;Applied sciences;biocompatibility;biocompatible materials;Biocompatible Materials - chemical synthesis;Biocompatible Materials - chemistry;Biocompatible Materials - pharmacology;Biological and medical sciences;calcium;Cell Adhesion - drug effects;cell biology;cell culture;Chitosan;Chitosan - chemistry;Composite;crosslinking;Degradation;Electromagnetic Fields;Electrospinning;Exact sciences and technology;Fibers and threads;Forms of application and semi-finished materials;HEK293 Cells;Humans;hydrophobicity;ions;Materials Testing;Medical sciences;nanofibers;polyethylene glycol;Polymer industry, paints, wood;Polymers - chemical synthesis;Polymers - chemistry;Polymers - pharmacology;Surface modification;Surface Properties;Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases;Technology of polymers;Technology. Biomaterials. Equipments;tissue engineering;viability;viscosity
Date:	2013-06-20
Issue Date:	2026-04-21 14:12:25 (UTC+8)
Publisher:	Elsevier Ltd.;Kidlington: Elsevier Ltd
Abstract:	摘要： •The ratios of coelectrospun chitosan/alginate fibers are controlled by flow rates.•Surface properties can be modulated by the composition ratios of composite fibers.•Composite chitosan/alginate fibers demonstrate superior biocompatibilities.•Fiber compositions are dynamically regulated by the crosslinking levels of alginate. Chitosan and alginate are two frequently used biomaterials for tissue engineering. In this study, electrospinning technique was applied for their nanofiber fabrications to mimic extracellular environment (ECM). Polyethylene oxide (PEO) was applied to increase viscosities of polymer solutions to obtain nanofibers with appropriate morphologies. To modulate surface properties, a dual jet system was developed to coelectrospin chitosan and alginate nanofibers on one substrate. Because the deposition rates of electrospun fibers linearly correlated to the perfusion rates of polymer solutions, the composition ratios of nanofibers were thus manipulated, which determined both the chemical properties and hydrophobicity of fibrous mats. In vitro cell culture results suggested that the cell morphology highly depended on the fiber composition, and the composite nanofibers demonstrated higher biocompatibility than that on pure fibers. Finally, the degradation of alginate fibers was controlled by the crosslinking process. Reducing calcium ions resulted in partial fiber degradation, by which the composition ratios of nanofibers varied with time. This dynamically changed environment performed a promising property to improve viability of surface cells. Through this tunable system, surface properties of scaffolds can be finely adjusted to benefit tissue engineering applications. 其他題名： Carbohydr Polym 出版者： Kidlington: Elsevier Ltd 出版日期： 2013-06-20 出處： Carbohydrate Polymers, 2013-06, Vol.95 (2), p.716-727 資源來源： PubMed 版權： 2013 Elsevier Ltd 版權： 2014 INIST-CNRS 版權： Copyright © 2013 Elsevier Ltd. All rights reserved. 識別號： ISSN: 0144-8617 識別號： ISSN: 1879-1344 識別號： EISSN: 1879-1344 識別號： DOI: 10.1016/j.carbpol.2013.02.083 識別號： PMID: 23648033 識別號： CODEN: CAPOD8
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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