Structural characteristics and fusion pathways of onion-like multilayered polymersome formed by amphiphilic comb-like graft copolymers

NCU Institutional Repository > 工學院 > 化學工程與材料工程學系 > 期刊論文 > Item 987654321/100763

請使用永久網址來引用或連結此文件: https://ir.lib.ncu.edu.tw/handle/987654321/100763

題名:	Structural characteristics and fusion pathways of onion-like multilayered polymersome formed by amphiphilic comb-like graft copolymers
作者:	曹恆光;Chang, Hung-Yu;Lin, Yung-Lung;Sheng, Yu-Jane;Tsao, Heng-Kwong
貢獻者:	工學院化學工程與材料工程學系
關鍵詞:	anisotropy;Applied sciences;Biological and medical sciences;composite polymers;deformation;drugs;Exact sciences and technology;General pharmacology;hydrophilicity;hydrophobicity;Medical sciences;membrane permeability;molecular dynamics;onions;Organic polymers;Pharmaceutical technology. Pharmaceutical industry;Pharmacology. Drug treatments;physical phases;Physicochemistry of polymers;Properties and characterization;Solution and gel properties;solvents
日期:	2013-07-23
上傳時間:	2026-04-21 14:13:22 (UTC+8)
出版者:	American Chemical Society;Washington, DC: American Chemical Society
摘要:	摘要： The self-assembly behavior of amphiphilic comb-like graft copolymers bearing pH-responsive hydrophilic side-chains on hydrophobic backbone in a selective solvent is investigated by dissipative particle dynamics. The aggregate exhibits a rich variety of the morphological conformations dependent on pH, polymeric concentration, side-chain length, and grafting density. The morphological phase diagram shows that micellar aggregates take shape at low pH. As pH increases, unilamellar vesicle (ULV) can form at low polymer concentration and the vesicle size grows with increasing concentration. Further increment of pH to neutral leads to the formation of multilamellar vesicles (MLV) with the layer-by-layer structure similar to that of an onion. The total number of layers rises with increasing polymer concentration. Our simulation outcomes are consistent with the experimental observations. The simulation results also reveal that as the grafting density is decreased, the thickness of the hydrophobic layer grows and thus the total number of layers declines for MLVs. The water permeation process through ULV is monitored to explore the effects of grafting density and pH on the membrane permeability. As the grafting density is decreased or the neutral pH is approached, the permeability of the vesicle membrane descends. Controlled releases of two types of drugs with different hydrophobicity situated at different layers of MLV are also examined. The release rate of hydrophilic drug is faster than that of hydrophobic drug. Polymersomes tend to fuse but the fusion mechanism is different from that of liposomes. The fusion pathway of ULVs follows the anisotropic stalk-pore scenario and both stalk and pore formation prefer to occur on the edge of the contact zone due to significant deformations of comb-like polymers in this region. The fusion pathway of MLVs is layer-by-layer and the fusion time of the inner layer is faster than that of the outer layer. The fusion process is expedited at about neutral pH but is prolonged substantially as the side-chain length is increased. Finally, it is interesting to observe that the total number of layers of the fused MLV can be greater than that of MLVs before fusion. 其他題名： Macromolecules 出版者： Washington, DC: American Chemical Society 出版日期： 2013-07-23 出處： Macromolecules, 2013-07, Vol.46 (14), p.5644-5656 資源來源： American Chemical Society Journals 版權： Copyright © 2013 American Chemical Society 版權： 2014 INIST-CNRS 識別號： ISSN: 0024-9297 識別號： ISSN: 1520-5835 識別號： EISSN: 1520-5835 識別號： DOI: 10.1021/ma400667n 識別號： CODEN: MAMOBX
顯示於類別:	[化學工程與材料工程學系 ] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
index.html		0Kb	HTML	16	檢視/開啟

在NCUIR中所有的資料項目都受到原著作權保護.

社群 sharing

資料載入中.....