Engineering reaction and crystallization and the impact on filtration, drying, and dissolution behaviors: The study of acetaminophen (paracetamol) by in-process controls

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Title:	Engineering reaction and crystallization and the impact on filtration, drying, and dissolution behaviors: The study of acetaminophen (paracetamol) by in-process controls
Authors:	李弘霖;Lee, Tu;Lin, Hong Yu;Lee, Hung Lin
Contributors:	工學院化學工程與材料工程學系
Date:	2013-09-20
Issue Date:	2026-04-21 14:14:41 (UTC+8)
Publisher:	American Chemical Society
Abstract:	摘要： Acetaminophen was synthesized by reacting p-aminophenol with acetic anhydride. Overall materials balance was compiled. Three different crystallization paths (i.e., cases I, II, and III) involving various modes in agitation and addition of sodium hydroxide were taken to produce acetaminophen particles with different particle size distributions (PSDs) and polymorphism. The concentration profile of acetaminophen, temperature, and pH values throughout reaction and crystallization were monitored mainly by in-process control (IPC). The rates of nucleation, crystal growth, and agglomeration during crystallization were quantified by the mixed-suspension mixed-product removal (MSMPR) formalism. The average specific cake resistance for filtration, Krischer rate-moisture plot for drying, Carr’s index for powder flowability, and dissolution rate for drug delivery of acetaminophen crystals generated in cases I, II, and III were thoroughly studied and compared. 其他題名： Org. Process Res. Dev 出版者： American Chemical Society 出版日期： 2013-09-20 出處： Organic process research & development, 2013-09, Vol.17 (9), p.1168-1178 資源來源： ACS publications 版權： Copyright © 2013 American Chemical Society 識別號： ISSN: 1083-6160 識別號： EISSN: 1520-586X 識別號： DOI: 10.1021/op400129n
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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