Pd-catalyzed direct C-H arylation of thieno[3,4-c]pyrrole-4,6-dione (TPD): A step-economical synthetic alternative to access TPD-centred symmetrical small molecules

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Title:	Pd-catalyzed direct C-H arylation of thieno[3,4-c]pyrrole-4,6-dione (TPD): A step-economical synthetic alternative to access TPD-centred symmetrical small molecules
Authors:	劉青原;Chang, Shan-Yun;Lin, Po-Han;Liu, Ching-Yuan
Contributors:	工學院化學工程與材料工程學系
Keywords:	aldehydes;arylation;carbon-hydrogen bond activation;catalysts;catalytic activity;Derivatives;Esters;Ketones;Ligands;moieties;Nitriles;Optimization;Palladium;Screening
Date:	2014-01-01
Issue Date:	2026-04-21 14:20:35 (UTC+8)
Publisher:	Royal Society of Chemistry
Abstract:	摘要： We demonstrate a step-economical and viable synthetic alternative to access a series of thieno[3,4- c ]pyrrole-4,6-dione (TPD)-based π-conjugated molecules through Pd-catalyzed direct C–H arylations. A comprehensive synthetic study including the screening of various kinds of palladium catalysts, ligands, and bases is reported. Under the optimum reaction conditions, TPD and its common derivatives underwent efficient and mild direct C–H arylations with a variety of functionalized bromoarenes. Functional groups such as ester, nitrile, ketone, aldehyde, and halide were well-tolerated, which substantially extended the reaction scope. We hope the reported method will provide materials scientists a relatively greener synthetic route to efficiently prepare TPD-containing π-functional materials. 出版日期： 2014-01-01 出處： RSC advances, 2014-01, Vol.4 (68), p.35868-35878 資源來源： Royal Society of Chemistry 識別號： ISSN: 2046-2069 識別號： EISSN: 2046-2069 識別號： DOI: 10.1039/C4RA05380J
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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