Phase behaviors and membrane properties of model liposomes: Temperature effect

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Title:	Phase behaviors and membrane properties of model liposomes: Temperature effect
Authors:	曹恆光;Wu, Hsing-Lun;Sheng, Yu-Jane;Tsao, Heng-Kwong
Contributors:	工學院化學工程與材料工程學系
Keywords:	Computer Simulation;Elasticity;Gels - chemistry;High temperature;Lipid Bilayers - chemistry;Lipids;Liposomes;Liposomes - chemistry;Liquid phases;Marsileaceae;Mechanical properties;Permeability;Phase Transition;Phase transitions;Physics;Shape;Temperature;Temperature effects;Vesicles
Date:	2014-01-01
Issue Date:	2026-04-21 14:20:40 (UTC+8)
Publisher:	American Institute of Physics;United States: American Institute of Physics
Abstract:	摘要： The phase behaviors and membrane properties of small unilamellar vesicles have been explored at different temperatures by dissipative particle dynamics simulations. The vesicles spontaneously formed by model lipids exhibit pre-transition from gel to ripple phase and main transition from ripple to liquid phase. The vesicle shape exhibits the faceted feature at low temperature, becomes more sphere-like with increasing temperature, but loses its sphericity at high temperature. As the temperature rises, the vesicle size grows but the membrane thickness declines. The main transition (Tm) can be identified by the inflection point. The membrane structural characteristics are analyzed. The inner and outer leaflets are asymmetric. The length of the lipid tail and area density of the lipid head in both leaflets decrease with increasing temperature. However, the mean lipid volume grows at low temperature but declines at high temperature. The membrane mechanical properties are also investigated. The water permeability grows exponentially with increasing T but the membrane tension peaks at Tm. Both the bending and stretching moduli have their minima near Tm. Those results are consistent with the experimental observations, indicating that the main signatures associated with phase transition are clearly observed in small unilamellar vesicles. 其他題名： J Chem Phys 出版者： United States: American Institute of Physics 出版日期： 2014-09-28 出處： The Journal of chemical physics, 2014-09, Vol.141 (12), p.124906 資源來源： AIP Journals (American Institute of Physics) 版權： 2014 AIP Publishing LLC. 識別號： ISSN: 0021-9606 識別號： ISSN: 1089-7690 識別號： EISSN: 1089-7690 識別號： DOI: 10.1063/1.4896382 識別號： PMID: 25273473
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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