In situ surface tailoring with zwitterionic carboxybetaine moieties on self-assembled thin film for antifouling biointerfaces

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Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/101067

Title:	In situ surface tailoring with zwitterionic carboxybetaine moieties on self-assembled thin film for antifouling biointerfaces
Authors:	黃俊仁;Huang, Chun-Jen;Chang, Ying-Chih
Contributors:	工學院化學工程與材料工程學系
Keywords:	Adsorption;Amines;Antifouling;Biocompatibility;Blood;Blood cells;Contact angle;Electrons;Engineering;Medical equipment;Microbalances;Protective coatings;Proteins;Surface chemistry;Thin films;Thrombosis
Date:	2014-02-12
Issue Date:	2026-04-21 14:22:32 (UTC+8)
Publisher:	MDPI AG;Switzerland: MDPI AG
Abstract:	摘要： A novel biointerface bearing zwitterionic carboxybetaine moieties was developed for effective resistance to nonspecific adsorption of proteins and blood cells. Self-assembled thin films (SAFs) of (N,N-dimethylaminopropyl) trimethoxysilane were formed as mattress layers by either vapor or solution deposition. Subsequently, the tertiary amine head groups on SAFs were reacted with β-propiolactone to give zwitterionic carboxybetaine moieties via in situ synthesis. The optimal reaction time of 8 h for both preparation methods was verified by static contact angle measurements. According to the X-ray photoelectron spectroscopy, 67.3% of amine groups on SAFs prepared from the vapor deposition was converted to the zwitterionic structures after reaction of β-propiolactone. The antifouling properties of the zwitterionic biointerfaces were quantitatively evaluated in the presence of protein solutions using a quartz crystal microbalance with dissipation, showing a great improvement by factors of 6.5 and 20.2 from tertiary amine SAFs and bare SiO2 surfaces, respectively. More importantly, the zwitterionic SAFs were brought to contact with undiluted human blood in chaotic-mixer microfluidic systems; the results present their capability to effectively repel blood cell adhesion. Accordingly, in this work, development of carboxybetaine SAFs offers a facile yet effective strategy to fabricate biocompatible biointerfaces for a variety of potential applications in surface coatings for medical devices. 其他題名： Materials (Basel) 出版者： Switzerland: MDPI AG 出版日期： 2014-01-01 出處： Materials, 2014-01, Vol.7 (1), p.130-142 資源來源： Publicly Available Content Database 版權： Copyright MDPI AG 2014 版權： 2013 by the authors. 2013 識別號： ISSN: 1996-1944 識別號： EISSN: 1996-1944 識別號： DOI: 10.3390/ma7010130 識別號： PMID: 28788445
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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