Surface self-assembled zwitterionization of poly(vinylidene fluoride) microfiltration membranes via hydrophobic-driven coating for improved blood compatibility

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Title:	Surface self-assembled zwitterionization of poly(vinylidene fluoride) microfiltration membranes via hydrophobic-driven coating for improved blood compatibility
Authors:	樋口亞紺;Venault, Antoine;Chang, Yung;Yang, Hui-Shan;Lin, Pei-Ying;Shih, Yu-Ju;Higuchi, Akon
Contributors:	工學院化學工程與材料工程學系
Keywords:	adhesion;adsorption;Applied sciences;artificial membranes;Blood;blood plasma;Brushes;Chemistry;coagulation;coatings;Colloidal state and disperse state;composite polymers;Copolymers;Exact sciences and technology;Exchange resins and membranes;fibrinogen;Fluorides;Forms of application and semi-finished materials;General and physical chemistry;Human;humans;hydrophilicity;hydrophobicity;Membranes;microfiltration;molecular weight;Polymer industry, paints, wood;polymerization;Polyvinylidene fluorides;propylene oxide;Surface chemistry;Technology of polymers;zwitterions
Date:	2014-03-15
Issue Date:	2026-04-21 14:23:39 (UTC+8)
Publisher:	Elsevier;Amsterdam: Elsevier BV
Abstract:	摘要： A facile surface self-assembled zwitterionization process is presented, aiming at improving the blood compatibility of poly(vinylidene fluoride) (PVDF) membranes. Zwitterionic diblock copolymers containing hydrophobic propylene oxide and hydrophilic sulfobetaine methacrylate blocks were prepared with well controlled molecular weights via atom-transfer radical polymerization (ATRP). Poly(propylene oxide)-block-poly(sulfobetaine methacrylate) (PPO-b-PSBMA) copolymers with varying zwitterionic PSBMA lengths were coated by self-assembling process onto the surface of PVDF microfiltration membranes in order to enhance their surface hydrophilicity and protein resistance. A systematic study regarding the effect of block lengths of PPO-b-PSBMA copolymers on the hemocompatibility of zwitterionic PVDF membranes in human blood solution was then performed. Protein adsorption from single-protein solutions and 100% blood plasma solutions was measured on the PVDF surfaces covered with PPO-b-PSBMA brushes. If the increase in PPO content in copolymer increased the efficiency of coating on the membrane, resistance to human fibrinogen adsorption was enhanced when increasing the PSBMA content. The control of the anchoring structures of zwitterionic copolymer layers highly regulates the adsorption of plasma proteins, the adhesion of platelets, and the coagulation of human plasma. PVDF membranes coated with PPO-b-PSBMA containing a high amount of zwitterionic SBMA units presented a high hydration capability, believed to allow improving significantly the hemocompatible character of PVDF membranes. This work suggests that the hemocompatible nature of self-assembled zwitterionic brushes gives them a great potential in the molecular design of antithrombogenic membranes for use in human blood applications. 出版者： Amsterdam: Elsevier BV 出版日期： 2014-03-01 出處： Journal of Membrane Science, 2014-03, Vol.454, p.253-263 版權： 2015 INIST-CNRS 識別號： ISSN: 0376-7388 識別號： DOI: 10.1016/j.memsci.2013.11.050 識別號： CODEN: JMESDO
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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