Self-assembled polymersomes formed by symmetric, asymmetric and side-chain-tethered coil-rod-coil triblock copolymers

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Title:	Self-assembled polymersomes formed by symmetric, asymmetric and side-chain-tethered coil-rod-coil triblock copolymers
Authors:	曹恆光;Lin, Yung-Lung;Chang, Hung-Yu;Sheng, Yu-Jane;Tsao, Heng-Kwong
Contributors:	工學院化學工程與材料工程學系
Keywords:	Asymmetry;Coiling;Copolymers;Membranes;Micelles;Rods;Self assembly;Solvents
Date:	2014-03-21
Issue Date:	2026-04-21 14:24:22 (UTC+8)
Publisher:	Royal Society of Chemistry;England
Abstract:	摘要： Self-assembly behaviors of coil-rod-coil copolymers in selective solvents are explored by dissipative particle dynamics. The morphological phase diagram as a function of rod length and coil length shows five distinct types of aggregates, including spherical micelles, worm-like micelles, disk-like aggregates, honeycomb structures, and polymersomes. Small polymersomes are formed at rather poor alignment associated with monolayered rod domains. Some of the rods are even lying perpendicular to the radial direction. For symmetric copolymers (C m R x C m ), the condition of vesicle formation is restricted to short coil and rod lengths. To favor the formation of CRC-polymersomes, two architecture modifications are adopted. One is to increase the coil length asymmetrically to be C m R x C n , where n > m . The other one is to tether a T-block onto the middle of the rod-block as C m (R x T y )C m copolymers. For those CRC-polymersomes, structural, transport, and mechanical properties of the vesicular membrane are determined, including membrane thickness, area density of coil blocks, order parameter, solvent permeability, frequency of flip-flop, membrane tension, and stretching and bending moduli. The influences of the coil length ( n ) and tethered block length ( y ) on membrane properties are examined. Finally, the mechanism of membrane fusion between CRC-polymersomes is investigated. The fusion process involves four stages and in the contact region the rods lying perpendicular to the radial direction of the polymersome play the key role. The encounter of two vesicles may result in a fused, hemifused, or non-fused polymersome. The final fate is determined by the competition between membrane tension and the steric barrier of the coil corona. The fusion outcome may change if the tension is altered by manipulating the lumen pressure. Molecular arrangement within a membrane of polymersomes formed by symmetric and side-chain tethered coil-rod-coil triblock copolymers. 其他題名： Soft Matter 出版者： England 出版日期： 2014-03-21 出處： Soft matter, 2014-03, Vol.1 (11), p.184-1852 識別號： ISSN: 1744-683X 識別號： ISSN: 1744-6848 識別號： EISSN: 1744-6848 識別號： DOI: 10.1039/c3sm52916a 識別號： PMID: 24651905
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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