Suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments

NCUIR > Engineering College > Department of Chemical and Materials Engineering > journal & Dissertation > Item 987654321/101127

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Title:	Suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments
Authors:	樋口亞紺;Kao, Ta-Chun;Lee, Henry Hsin-chung;Higuchi, Akon;Ling, Qing-Dong;Yu, Wan-Chun;Chou, Yu-Hsuan;Wang, Pin-Yu;Suresh Kumar, S.;Chang, Yu;Hung Chen, Yung;Chang, Yung;Chen, Da-Chung;Hsu, Shih-Tien
Contributors:	工學院化學工程與材料工程學系
Keywords:	Adipocytes - physiology;Aged;Aged, 80 and over;Animals;Biocompatible Materials;Biological and medical sciences;Biomaterials;Biomedical materials;Bulging;Cancer;Cell Differentiation;Cell Line, Tumor;cell-sorting dish;Cells, Cultured;Colon;Colonic Neoplasms - pathology;Culture;extracellular matrix;Gene Expression Regulation, Neoplastic - genetics;Gene Expression Regulation, Neoplastic - physiology;Humans;Immunohistochemistry;Materials research;Materials science;Medical sciences;Mice;Middle Aged;nanosegment;Nanostructure;Neoplasm Transplantation;Neoplastic Stem Cells - physiology;Pluronic;Poloxamer;Polystyrenes;stem cell;Stem cells;Stem Cells - physiology;Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases;Surgical implants;Technology. Biomaterials. Equipments
Date:	2014-04-01
Issue Date:	2026-04-21 14:24:55 (UTC+8)
Publisher:	John Wiley and Sons Inc.;Hoboken, NJ: Blackwell Publishing Ltd
Abstract:	摘要： AbstractCancer‐initiating cells [cancer stem cells (CSCs)] in colon cancer cells can be selectively suppressed when they are cultured on Pluronic (nanosegment)‐grafted dishes, whereas CSCs are maintained on conventional tissue culture dishes and extracellular matrix‐coated dishes. CSCs persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumorigenic clones. The purification or depletion (suppression) of CSCs should be useful for analyzing CSC characteristics and for clinical application. CSCs can be selectively suppressed from colon cancer cells containing adipose‐derived stem cells (ADSCs) on Pluronic‐grafted dishes, while ADSCs remain on the dishes. ADSCs on Pluronic‐grafted dishes after the suppression of the CSCs can differentiate into osteoblasts, chondrocytes, adipocytes, cardiomyocytes, and neuronal cells. The CSCs and ADSCs exhibited different characteristics. The selection of ADSCs was possible on Pluronic‐grafted dishes that suppressed the CSCs from the fat tissues of cancer patients (i.e., cell‐sorting dishes), which was explained by specific biomedical characteristics of Pluronic. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 463–476, 2014. 其他題名： J. Biomed. Mater. Res 出版者： Hoboken, NJ: Blackwell Publishing Ltd 出版日期： 2014-04-01 出處： Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2014-04, Vol.102 (3), p.463-476 資源來源： Alma/SFX Local Collection 版權： 2015 INIST-CNRS 版權： Copyright © 2013 Wiley Periodicals, Inc. 識別號： ISSN: 1552-4973 識別號： ISSN: 1552-4981 識別號： EISSN: 1552-4981 識別號： DOI: 10.1002/jbm.b.33024 識別號： PMID: 24039170
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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