Large-scale crystallization of a pure metastable polymorph by reaction coupling

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題名:	Large-scale crystallization of a pure metastable polymorph by reaction coupling
作者:	李度;Lee, Hung Lin;Lin, Hong Yu;Lee, Tu
貢獻者:	工學院化學工程與材料工程學系
日期:	2014-04-18
上傳時間:	2026-04-21 14:25:21 (UTC+8)
出版者:	American Chemical Society
摘要:	摘要： A maximum of more than 40 g of acetaminophen Form II crystals with a yield of 65 mol % is made reproducibly in a 500 mL reactor by coupling the acetylation of p-aminophenol with the neutralization of acetic acid before the crystallization of acetaminophen Form II crystals. This novel working principle involves a sudden drop of the solubility of acetaminophen from the acetic acid–water environment to the acetate–water system in addition to temperature cooling but without agitation. This particular processing pathway is capable of maintaining a large supersaturation for quite some time for the system to enter the metastable zone of Form II with respect to the acetate–water system. The large amount of Form II crystals so produced are then isolated by filtration and oven drying to prevent Form II crystals in the mother liquor from transforming to the thermodynamically stable Form I crystals by the Ostwald’s rule of stages. 其他題名： Org. Process Res. Dev 出版者： American Chemical Society 出版日期： 2014-04-18 出處： Organic process research & development, 2014-04, Vol.18 (4), p.539-545 資源來源： American Chemical Society Journals 版權： Copyright © American Chemical Society 識別號： ISSN: 1083-6160 識別號： EISSN: 1520-586X 識別號： DOI: 10.1021/op500003k
顯示於類別:	[化學工程與材料工程學系 ] 期刊論文

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