Hemocompatibility of polyampholyte copolymers with well-defined charge bias in human blood

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Title:	Hemocompatibility of polyampholyte copolymers with well-defined charge bias in human blood
Authors:	樋口亞紺;Shih, Yu-Ju;Chang, Yung;Quemener, Damien;Yang, Hui-Shan;Jhong, Jheng-Fong;Ho, Feng-Ming;Higuchi, Akon;Chang, Yu
Contributors:	工學院化學工程與材料工程學系
Keywords:	anticoagulants;Biocompatible Materials - adverse effects;Biocompatible Materials - chemistry;blood plasma;body temperature;Chemical Sciences;composite polymers;copolymerization;free radicals;Humans;hydrodynamics;Methacrylates - chemistry;Polymers - adverse effects;Polymers - chemistry;zwitterions
Date:	2014-06-10
Issue Date:	2026-04-21 14:26:48 (UTC+8)
Publisher:	American Chemical Society;United States: American Chemical Society
Abstract:	摘要： In this work, the hemocompatibility of polyampholyte copolymers from the mixed-charge copolymerization of negatively charged 3-sulfopropyl methacrylate (SA) and positively charged [2-(methacryloyloxy)ethyl] trimethylammonium (TMA) was studied. Charge-bias variation of the prepared poly(SA-co-TMA) copolymers can be controlled using the regulated SA and TMA monomer ratio via homogeneous free radical copolymerization. A systematic study of how charge-bias variations in poly(SA-co-TMA) copolymers affect the hemocompatibility in human blood plasma was reported. The hydrodynamic size of prepared polymers and copolymers is determined to illustrate the correlations between intermolecular cationic/anionic associations and the blood compatibility of polySA, poly(SA-co-TMA), and polyTMA suspensions in human blood plasma. It was found that the protein resistance and hydration capability of prepared copolymers can be effectively controlled by regulating the charge balance of the SA/TMA compositions in poly(SA-co-TMA). The results suggest that polyampholyte copolymers of poly(SA-co-TMA) with overall charge neutrality have a high hydration capability and the best antifouling, anticoagulant, and antihemolytic activities as well as zwitterionic sulfobetaine-based homopolymers when in contact with blood plasma at human body temperature. 其他題名： Langmuir 出版者： United States: American Chemical Society 出版日期： 2014-06-10 出處： Langmuir, 2014-06, Vol.30 (22), p.6489-6496 資源來源： American Chemical Society Journals 版權： licence_http://creativecommons.org/publicdomain/zero 識別號： ISSN: 0743-7463 識別號： ISSN: 1520-5827 識別號： EISSN: 1520-5827 識別號： DOI: 10.1021/la5015779 識別號： PMID: 24832682
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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