Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instability

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題名:	Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instability
作者:	樋口亞紺;Fukawatase, Yoshihiro;Toyoda, Masashi;Okamura, Kohji;Nakamura, Ken-ichi;Nakabayashi, Kazuhiko;Takada, Shuji;Yamazaki-Inoue, Mayu;Masuda, Akira;Nasu, Michiyo;Hata, Kenichiro;Hanaoka, Kazunori;Higuchi, Akon;Takubo, Kaiyo;Umezawa, Akihiro
貢獻者:	工學院化學工程與材料工程學系
關鍵詞:	13;13/100;45;45/23;631/532/2064/2158;692/699/375/2764;Animals;Apoptosis;Apoptosis - radiation effects;Ataxia;Ataxia Telangiectasia;Ataxia Telangiectasia - genetics;Ataxia Telangiectasia - pathology;Ataxia Telangiectasia - radiotherapy;Ataxia telangiectasia mutated protein;Ataxia Telangiectasia Mutated Proteins;Ataxia Telangiectasia Mutated Proteins - genetics;Blotting, Western;Cell death;Cell Differentiation;Cell Differentiation - radiation effects;Cell Proliferation;Cell Proliferation - radiation effects;Cells, Cultured;Cellular Reprogramming;Child;Chromosomal Instability;Chromosomal Instability - radiation effects;Chromosome aberrations;Exome;Exome - genetics;Fluorescent Antibody Technique;Genomic instability;High-Throughput Nucleotide Sequencing;Humanities and Social Sciences;Humans;Hypersensitivity;Immunoenzyme Techniques;In Situ Hybridization, Fluorescence;Induced Pluripotent Stem Cells;Induced Pluripotent Stem Cells - cytology;Induced Pluripotent Stem Cells - metabolism;Induced Pluripotent Stem Cells - radiation effects;Ionizing radiation;Irradiation;Karyotyping;Male;Mice;Mice, Inbred NOD;Mice, SCID;multidisciplinary;Radiation Tolerance;Radiation Tolerance - genetics;Real-Time Polymerase Chain Reaction;Reverse Transcriptase Polymerase Chain Reaction;RNA, Messenger;RNA, Messenger - genetics;Science;Teratoma;Teratoma - genetics;Teratoma - pathology;Teratoma - radiotherapy;X-Rays
日期:	2014-06-27
上傳時間:	2026-04-21 14:26:58 (UTC+8)
出版者:	Nature Publishing Group;London: Springer Science and Business Media LLC
摘要:	摘要： AbstractAtaxia telangiectasia is a neurodegenerative inherited disease with chromosomal instability and hypersensitivity to ionizing radiation. iPS cells lacking ATM (AT-iPS cells) exhibited hypersensitivity to X-ray irradiation, one of the characteristics of the disease. While parental ataxia telangiectasia cells exhibited significant chromosomal abnormalities, AT-iPS cells did not show any chromosomal instability in vitro for at least 80 passages (560 days). Whole exome analysis also showed a comparable nucleotide substitution rate in AT-iPS cells. Taken together, these data show that ATM is involved in protection from irradiation-induced cell death. 其他題名： Sci Rep 出版者： London: Springer Science and Business Media LLC 出版日期： 2014-06-27 出處： Scientific Reports, 2014-06, Vol.4 (1), p.5421-, Article 5421 資源來源： Publicly Available Content Database 版權： The Author(s) 2014 版權： Copyright Nature Publishing Group Jun 2014 版權： Copyright © 2014, Macmillan Publishers Limited. All rights reserved 2014 Macmillan Publishers Limited. All rights reserved 識別號： ISSN: 2045-2322 識別號： EISSN: 2045-2322 識別號： DOI: 10.1038/srep05421 識別號： PMID: 24970375
顯示於類別:	[化學工程與材料工程學系 ] 期刊論文

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