Surface zwitterionization of titanium for a general bio-inert control of plasma proteins, blood cells, tissue cells, and bacteria

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題名:	Surface zwitterionization of titanium for a general bio-inert control of plasma proteins, blood cells, tissue cells, and bacteria
作者:	樋口亞紺;Yu, Bo-Yi;Zheng, Jie;Chang, Yung;Sin, Mei-Chan;Chang, Chih-Hung;Higuchi, Akon;Sun, Yi-Ming
貢獻者:	工學院化學工程與材料工程學系
關鍵詞:	bacteria;bacterial adhesion;biocompatibility;Blood Cells - chemistry;blood platelets;blood proteins;Blood Proteins - chemistry;coatings;dopamine;erythrocytes;Escherichia coli;Escherichia coli - chemistry;Fibroblasts;fouling;Humans;leukocytes;polymers;silane;Staphylococcus epidermidis;Surface Properties;titanium;Titanium - chemistry;zwitterions
日期:	2014-07-01
上傳時間:	2026-04-21 14:27:05 (UTC+8)
出版者:	American Chemical Society;United States: American Chemical Society
摘要:	摘要： Surface coating of antifouling materials on the substrates offers convenient strategies and great opportunities to improve their biocompatibility and functions of host substrates for wide biomedical applications. In this work, we present a general surface zwitterionization strategy to improve surface biocompatibility and antifouling properties of titanium (Ti) by grafting zwitterionic poly(sulfobetaine methacrylate) (polySBMA). This method also demonstrates its general applicability to graft polySBMA onto Ti surface using different anchoring agents of dopamine and silane. The resulting polySBMA grafted from dopamine- (pTi-D-pSBMA) and silane-anchored titanium surfaces (pTi-Si-pSBMA) surfaces exhibit superlow fouling ability to highly resist the adhesions of plasma proteins, platelets, erythrocytes, leukocytes, human fibroblast (HT1080), E. coli, and S. epidermidis. The interfacial properties of the surface-modified Ti surfaces are analyzed and correlated with their antifouling properties. The new method and materials provide a more general, flexible, and robust way to produce an excellent nonfouling surface with adjustable interfacial structures of grafted polymers, which hopefully can be expanded to wider applications based on both the structure and surface superiorities. 其他題名： Langmuir 出版者： United States: American Chemical Society 出版日期： 2014-07-01 出處： Langmuir, 2014-07, Vol.30 (25), p.7502-7512 資源來源： American Chemical Society Journals 識別號： ISSN: 0743-7463 識別號： ISSN: 1520-5827 識別號： EISSN: 1520-5827 識別號： DOI: 10.1021/la500917s 識別號： PMID: 24913288
顯示於類別:	[化學工程與材料工程學系 ] 期刊論文

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