Modification of silicone elastomer with zwitterionic silane for durable antifouling properties

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題名:	Modification of silicone elastomer with zwitterionic silane for durable antifouling properties
作者:	陳文逸;Yeh, Shiou-Bang;Chen, Chien-Sheng;Chen, Wen-Yih;Huang, Chun-Jen
貢獻者:	工學院化學工程與材料工程學系
關鍵詞:	adhesion;adsorption;Animals;bacteria;Bacterial Adhesion - drug effects;biofouling;Biofouling - prevention & control;calcification;contact angle;crosslinking;cytotoxicity;elemental composition;engineering;Fibroblasts;hydrogels;Hydrophobic and Hydrophilic Interactions - drug effects;hydrophobicity;lipids;Lipids - chemistry;medical equipment;Mice;Molecular Structure;NIH 3T3 Cells;polydimethylsiloxane;proteins;Proteins - chemistry;Pseudomonas aeruginosa - chemistry;Pseudomonas aeruginosa - drug effects;silane;Silanes - chemistry;Silicone Elastomers - chemistry;Silicone Elastomers - pharmacology;Staphylococcus epidermidis - chemistry;Staphylococcus epidermidis - drug effects;Surface Properties;thrombosis;X-ray photoelectron spectroscopy;zwitterions
日期:	2014-09-30
上傳時間:	2026-04-21 14:28:55 (UTC+8)
出版者:	American Chemical Society;United States: American Chemical Society
摘要:	摘要： Biofouling on medical devices generally causes adverse complications, such as thrombosis, infection, and pathogenic calcification. Silicone is a widely used material for medical applications. Its surface modification typically encounters undesirable “hydrophobic recovery”, leading to deterioration of surface engineering. In this study, we developed a stable superhydrophilic zwitterionic interface on polydimethylsiloxane (PDMS) elastomer by covalent silanization of sulfobetaine silane (SBSi) to resist nonspecific adsorption of bacteria, proteins, and lipids. SBSi is a zwitterionic organosilane assembly, enabling resisting surface reconstruction by forming a cross-linked network and polar segregation. Surface elemental composition was confirmed by X-ray photoelectron spectroscopy (XPS), and the long-term stability of modification was accessed using a contact angle goniometer. The biofouling tests were carried out by exposing substrates to bacterial, protein, and lipid solutions, revealing the excellent bioinertness of SBSi-tailored PDMS, even after 30 day storage in ambient. For the real-world application, we modified commercially available silicone hydrogel contact lenses with developed zwitterionic silane, presenting its antibacterial adhesion property. Moreover, the cytotoxicity of SBSi was accessed with NIH-3T3 fibroblast by the MTT assay, showing negligible cytotoxicity up to a concentration of 5 mM. Consequently, the strategy of surface engineering in this work can effectively retard the “hydrophobic recovery” occurrence and can be applied to other silicone-based medical devices in a facile way. 其他題名： Langmuir 出版者： United States: American Chemical Society 出版日期： 2014-09-30 出處： Langmuir, 2014-09, Vol.30 (38), p.11386-11393 資源來源： American Chemical Society Journals 識別號： ISSN: 0743-7463 識別號： ISSN: 1520-5827 識別號： EISSN: 1520-5827 識別號： DOI: 10.1021/la502486e 識別號： PMID: 25185951
顯示於類別:	[化學工程與材料工程學系 ] 期刊論文

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