摘要： Pharmaceutical co-crystals were assembled directly via chemical synthesis by cooling under three new strategies. The screening method for direct co-crystal assembly by a chemical reaction was developed based on liquid-assisted grinding. The ternary phase diagram including a chemical reaction and co-crystallization was established for a 2 : 1 co-crystal of benzoic acid-sodium benzoate. The ternary phase diagram for the direct assembly of a 2 : 1 co-crystal of benzoic acid-sodium benzoate was illustrated. Benzoic acid acted as a reactant and underwent neutralization to produce sodium benzoate. The excessive amount of benzoic acid as an API can interact with the product, sodium benzoate as another API, to undertake API-API co-crystallization by cooling. 出版日期： 2015-11-25 資源來源： Royal Society of Chemistry 識別號： EISSN: 1466-8033 識別號： DOI: 10.1039/c5ce01205h
