Generation of pluripotent stem cells without the use of genetic material

NCUIR > Engineering College > Department of Chemical and Materials Engineering > journal & Dissertation > Item 987654321/101375

Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/101375

Title:	Generation of pluripotent stem cells without the use of genetic material
Authors:	樋口亞紺;Higuchi, Akon;Ling, Qing-Dong;Kumar, S Suresh;Munusamy, Murugan A;Alarfaj, Abdullah A;Chang, Yung;Kao, Shih-Hsuan;Lin, Ke-Chen;Wang, Han-Chow;Umezawa, Akihiro
Contributors:	工學院化學工程與材料工程學系
Keywords:	13/100;42/109;631/61/2320;Animals;Genetic Techniques;Humans;Laboratory Medicine;Medicine;Medicine & Public Health;Mice;mini-review;Pathology;Pluripotent Stem Cells - cytology
Date:	2015-01-01
Issue Date:	2026-04-21 14:32:03 (UTC+8)
Publisher:	Nature Publishing Group;New York: Elsevier Inc
Abstract:	摘要： Induced pluripotent stem cells (iPSCs) provide a platform to obtain patient-specific cells for use as a cell source in regenerative medicine. Although iPSCs do not have the ethical concerns of embryonic stem cells, iPSCs have not been widely used in clinical applications, as they are generated by gene transduction. Recently, iPSCs have been generated without the use of genetic material. For example, protein-induced PSCs and chemically induced PSCs have been generated by the use of small and large (protein) molecules. Several epigenetic characteristics are important for cell differentiation; therefore, several small-molecule inhibitors of epigenetic-modifying enzymes, such as DNA methyltransferases, histone deacetylases, histone methyltransferases, and histone demethylases, are potential candidates for the reprogramming of somatic cells into iPSCs. In this review, we discuss what types of small chemical or large (protein) molecules could be used to replace the viral transduction of genes and/or genetic reprogramming to obtain human iPSCs. 其他題名： Lab Invest 出版者： New York: Elsevier Inc 出版日期： 2015-01-01 出處： Laboratory Investigation, 2015-01, Vol.95 (1), p.26-42 資源來源： Alma/SFX Local Collection 版權： 2014 United States & Canadian Academy of Pathology 版權： United States & Canadian Academy of Pathology 2014 版權： Copyright Nature Publishing Group Jan 2015 識別號： ISSN: 0023-6837 識別號： ISSN: 1530-0307 識別號： EISSN: 1530-0307 識別號： DOI: 10.1038/labinvest.2014.132 識別號： PMID: 25365202
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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