Cobalt-Catalyzed Reductive Alkylation of Heteroaryl Bromides: One-Pot Access to Alkylthiophenes, -furans, -selenophenes, and -pyrroles

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題名:	Cobalt-Catalyzed Reductive Alkylation of Heteroaryl Bromides: One-Pot Access to Alkylthiophenes, -furans, -selenophenes, and -pyrroles
作者:	劉青原;Cai, Deng-Jhou;Lin, Po-Han;Liu, Ching-Yuan
貢獻者:	工學院化學工程與材料工程學系
關鍵詞:	Alkylation;Cobalt;Heterocycles;Reduction
日期:	2015-08-01
上傳時間:	2026-04-21 14:38:08 (UTC+8)
出版者:	Wiley-VCH Verlag;Weinheim: WILEY-VCH Verlag
摘要:	摘要： A practical and convenient Co‐catalyzed alkylation method for the facile introduction of various alkyl chains into organic electronically significant heteroaryl compounds, including thiophenes, furans, selenophenes, and pyrroles, is reported. Under well‐optimized reaction conditions, a wide range of alkylated heteroaryl compounds have beeen efficiently prepared in moderate to good isolated yields. Notably, 2‐ or 3‐alkylthiophenes, which play a decisive role in polymer chemistry and organic materials, have been synthesized step‐economically for the first time by this reductive‐coupling methodology using inexpensive cobalt salts as catalysts. This straightforward synthetic procedure avoids the preparation of moisture‐unstable organometallic reagents (RMgX or RZnX) required in conventional alkylation protocols. Various alkyl chains have been introduced into organic, electronically important heteroaryl compounds step‐economically through Co‐catalyzed reductive alkylation reactions. The resulting alkylheteroarenes are indispensable building blocks for polymer chemistry and π‐functional organic materials. 其他題名： Eur. J. Org. Chem 出版者： Weinheim: WILEY-VCH Verlag 出版日期： 2015-08 出處： European journal of organic chemistry, 2015-08, Vol.2015 (24), p.5448-5452 資源來源： Wiley Online Library - AutoHoldings Journals 版權： Copyright © 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim 版權： Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 識別號： ISSN: 1434-193X 識別號： EISSN: 1099-0690 識別號： DOI: 10.1002/ejoc.201500784
顯示於類別:	[化學工程與材料工程學系 ] 期刊論文

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