Bio-inspired multifunctional catecholic assembly for photo-programmable biointerface

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題名:	Bio-inspired multifunctional catecholic assembly for photo-programmable biointerface
作者:	黃俊仁;Huang, Chun-Jen;Wang, Lin-Chuan
貢獻者:	工學院化學工程與材料工程學系
關鍵詞:	adhesion;adsorption;Antifouling;Antimony;Assembly;atomic force microscopy;Bacteria;Bacterial Adhesion;bacterial proteins;Bio-inspired materials;Biointerfaces;Biomaterials;Catecholic chemistry;Catechols - chemistry;colloids;contact angle;elemental composition;fouling;Interfaces;ligands;Microbalances;Microscopy, Atomic Force;nanomedicine;Photochemistry;Photoelectron Spectroscopy;Pseudomonas aeruginosa;Pseudomonas aeruginosa - physiology;quartz;Quartz Crystal Microbalance Techniques;Self-assembled monolayers;Staphylococcus epidermidis;Staphylococcus epidermidis - physiology;Titanium dioxide;ultraviolet radiation;wettability;X-ray photoelectron spectroscopy;Zwitterionic materials;zwitterions
日期:	2015-10-01
上傳時間:	2026-04-21 14:39:45 (UTC+8)
出版者:	Elsevier;Netherlands: Elsevier B.V
摘要:	摘要： [Display omitted] •We report a novel multifunctional mussel-inspired zwitterionic catecholic assembly to form a photoresponsive biointerface.•A self-assembled monolayer based on sulfobetaine nitrodopamine (SB-nDA) was formed by using a pH transition approach.•The SB-nDA film enables to effectively resist adsorption of proteins and bacteria.•The spatiotemporal control over the bioinertness of SB-nDA by UV irradiation is confirmed.•We demonstrated that the catecholic chemistry can be used for programmable tailoring of interfacial properties. This article reports a novel multifunctional mussel-inspired zwitterionic catecholic assembly to form a photoresponsive biointerface. The assembly is the combination of the antifouling sulfobetaine and photocleavable o-nitrophenyl moieties into a molecule, becoming sulfobetaine nitrodopamine (SB-nDA). We demonstrated the formation of a compact thin SB-nDA film on TiO2 by using the pH transition approach. The film thickness, surface wettability and elemental composition were characterized using ellipsometry, contact angle goniometer, atomic force microscopy and X-ray photoelectron spectroscopy, respectively. The SB-nDA thin films can effectively resist adhesion of both Gram-positive Staphylococcus epidermidis and Gram-negative Pseudomonas aeruginosa by more than 95% relative to bare TiO2. Quartz crystal microbalance with dissipation (QCM-D) sensor was employed for protein fouling tests, showing the comparable antifouling property of SB-nDA with thiol- or silane-based surface ligands. More importantly, the spatiotemporal control over the bioinertness by UV irradiation has been studied with bacterial and protein adsorption. Therefore, the catecholic chemistry can be used for programmable tailoring of interfacial properties, permitting potential application in light-guided targeting for nanomedicine. 其他題名： Colloids Surf B Biointerfaces 出版者： Netherlands: Elsevier B.V 出版日期： 2015-10-01 出處： Colloids and surfaces, B, Biointerfaces, 2015-10, Vol.134, p.247-253 版權： 2015 Elsevier B.V. 版權： Copyright © 2015 Elsevier B.V. All rights reserved. 識別號： ISSN: 0927-7765 識別號： ISSN: 1873-4367 識別號： EISSN: 1873-4367 識別號： DOI: 10.1016/j.colsurfb.2015.06.051 識別號： PMID: 26208296
顯示於類別:	[化學工程與材料工程學系 ] 期刊論文

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