| 摘要: | 摘要： Great care has been paid to the biointerface between a bulk material and the biological environment, which plays a key role in the optimized performance of medical devices. In this work, we report a new superhydrophilic adsorbate, called l-cysteine betaine (Cys-b), having branched zwitterionic groups that give rise to surfaces and nanoparticles with enhanced chemical stability, biofouling resistance, and inertness to environmental changes. Cys-b was synthesized from the amphoteric sulfur-containing amino acid, l-cysteine (Cys), by quaternization of its amino group. Gold surfaces modified with Cys-b exhibited prominent repellence against the nonspecific adsorption of proteins, bacteria, and fibroblast cells. In addition, Cys-b existed in zwitterionic form over a wide pH range (i.e., pH 3.4 to 10.8), and showed excellent suppression in photoinduced oxidation on gold substrates. Furthermore, the modification of hollow AgAu nanoshells with Cys-b gave rise to nanoparticles with excellent colloidal stability and resistance to coordinative interaction with Cu2+. Taken together, the unique features of Cys-b offer a new nanoscale coating for use in a wide spectrum of applications.
其他題名： ACS Appl. Mater. Interfaces
出版者： United States: American Chemical Society
出版日期： 2015-10-28
出處： ACS applied materials & interfaces, 2015-10, Vol.7 (42), p.23776-23786
資源來源： American Chemical Society Journals
版權： Copyright © 2015 American Chemical Society
識別號： ISSN: 1944-8244
識別號： ISSN: 1944-8252
識別號： EISSN: 1944-8252
識別號： DOI: 10.1021/acsami.5b08418
識別號： PMID: 26452141 |
