Mosquitocidal and antiplasmodial activity of Senna occidentalis (Cassiae) and Ocimum basilicum (Lamiaceae) from Maruthamalai hills against Anopheles stephensi and Plasmodium falciparum

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Title:	Mosquitocidal and antiplasmodial activity of Senna occidentalis (Cassiae) and Ocimum basilicum (Lamiaceae) from Maruthamalai hills against Anopheles stephensi and Plasmodium falciparum
Authors:	樋口亞紺;Murugan, Kadarkarai;Aarthi, Narayanan;Kovendan, Kalimuthu;Panneerselvam, Chellasamy;Chandramohan, Balamurugan;Kumar, Palanisamy Mahesh;Amerasan, Duraisamy;Paulpandi, Manickam;Chandirasekar, Ramachandran;Dinesh, Devakumar;Suresh, Udaiyan;Subramaniam, Jayapal;Higuchi, Akon;Alarfaj, Abdullah A.;Nicoletti, Marcello;Mehlhorn, Heinz;Benelli, Giovanni
Contributors:	工學院化學工程與材料工程學系
Keywords:	adults;Animals;Anopheles - drug effects;Anopheles stephensi;Antimalarials - pharmacology;Biomedical and Life Sciences;Biomedicine;chloroquine;hills;Immunology;inhibitory concentration 50;Insecticides - pharmacology;instars;Larva - drug effects;larvae;larvicides;leaf extracts;lethal concentration 50;malaria;Medical Microbiology;metabolites;Microbiology;mortality;mosquito-borne diseases;Ocimum basilicum;Ocimum basilicum - chemistry;Original Paper;people;Plant Extracts - chemistry;Plant Extracts - pharmacology;Plant Leaves - chemistry;Plasmodium falciparum;Plasmodium falciparum - drug effects;Pupa - drug effects;pupae;Senna occidentalis;Senna Plant - chemistry;smoke;toxicity
Date:	2015-10-13
Issue Date:	2026-04-21 14:40:26 (UTC+8)
Publisher:	Springer Verlag;Berlin/Heidelberg: Springer Berlin Heidelberg
Abstract:	摘要： Each year, mosquito-borne diseases infect nearly 700 million people, resulting to more than 1 million deaths. In this study, we evaluated the larvicidal, pupicidal, and smoke toxicity of Senna occidentalis and Ocimum basilicum leaf extracts against the malaria vector Anopheles stephensi. Furthermore, the antiplasmodial activity of plant extracts was evaluated against chloroquine (CQ)-resistant (CQ-r) and CQ-sensitive (CQ-s) strains of Plasmodium falciparum. In larvicidal and pupicidal experiments, S. occidentalis LC₅₀ ranged from 31.05 (I instar larvae) to 75.15 ppm (pupae), and O. basilicum LC₅₀ ranged from 29.69 (I instar larvae) to 69 ppm (pupae). Smoke toxicity experiments conducted against adults showed that S. occidentalis and O. basilicum coils evoked mortality rates comparable to the pyrethrin-based positive control (38, 52, and 42 %, respectively). In antiplasmodial assays, Senna occidentalis 50 % inhibitory concentration (IC₅₀) were 48.80 μg/ml (CQ-s) and 54.28 μg/ml (CQ-r), while O. basilicum IC₅₀ were 68.14 μg/ml (CQ-s) and 67.27 μg/ml (CQ-r). Overall, these botanicals could be considered as potential sources of metabolites to build newer and safer malaria control tools. 其他題名： Parasitol Res 出版者： Berlin/Heidelberg: Springer Berlin Heidelberg 出版日期： 2015-10-01 出處： Parasitology Research, 2015-10, Vol.114 (10), p.3657-3664 版權： Springer-Verlag Berlin Heidelberg 2015 識別號： ISSN: 0932-0113 識別號： EISSN: 1432-1955 識別號： DOI: 10.1007/s00436-015-4593-x 識別號： PMID: 26122992
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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