Annulated Mesoporous Silica as Potent Lanthanide Ion Adsorbents and Magnetic Resonance Contrast Enhancing Agents

Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/101674

Title:	Annulated Mesoporous Silica as Potent Lanthanide Ion Adsorbents and Magnetic Resonance Contrast Enhancing Agents
Authors:	謝發坤;Wang, Shao-Chun;Hsu, Yu-Shen;Hsiao, Chia-Teng;Wu, Chang-Cheng;Sue, Yu-Chein;Alshehri, Saad M.;Ahamad, Tansir;Yamauchi, Yusuke;Chen, Jeffrey E.;Wu, Kevin C.-W.;Shieh, Fa-Kuen
Contributors:	理學院化學學系
Keywords:	Aqueous-Solution;Chemistry;Chemistry and Materials Science;Complexes;Design;Drug-Delivery;Exchange;Heavy-Metal Ions;High-Relaxivity;Inorganic Chemistry;Lanthanoid(Iii) Ions;Nanoparticles;Organic Chemistry;Polymer Sciences;Spectroscopy
Date:	2016-01-01
Issue Date:	2026-04-21 14:40:34 (UTC+8)
Publisher:	Springer New York;New York: Springer Science and Business Media LLC
Abstract:	摘要： We report a series of SBA-15 type mesoporous silica (MS) possessing functional annulated rings of different sizes obtained by post-synthesis grafting with diamines containing backbones and different numbers of carbon atoms as efficient magnetic resonance imaging (MRI) contrasting agents. Interestingly, lanthanide ion adsorption assays in aqueous solutions of pH 7 at room temperature showed that adsorption efficiency was higher for materials with rings than those without rings. Furthermore, annulated MS synthesized with 1,5-diaminopetane exhibited selective chelation with smaller Yb(III) ions owing to the “macrocyclic effect” of the cation cavity that offers a “best fit.” Additionally, Gd(III) ions chelated with the material modified by 1, 5-diaminopetane denoted as Gdannulated-MS exhibited high r2/r1 relaxivities of 12, 12, and 28 while measured with 7.0 T (300 MHz), 9.4 T (400 MHz), and 11.4 T (500 MHz), respectively. Finally, the nanoscale parent materials for annulated modification were successfully synthesized for further in vivo applications. The MS materials thus obtained open auxiliary avenues for selective lanthanide ion absorption via manipulation of the annular ring size to be potentially applied in new generation MRI contrast agents. 其他題名： J Inorg Organomet Polym 出版者： New York: Springer Science and Business Media LLC 出版日期： 2016-01-01 出處： Journal of Inorganic and Organometallic Polymers and Materials, 2016-01, Vol.26 (1), p.165-171 版權： Springer Science+Business Media New York 2015 識別號： ISSN: 1574-1443 識別號： EISSN: 1574-1451 識別號： DOI: 10.1007/s10904-015-0280-8
Appears in Collections:	[Department of Chemistry] journal & Dissertation

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