Seaweed-synthesized silver nanoparticles: an eco-friendly tool in the fight against Plasmodium falciparum and its vector Anopheles stephensi?

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Title:	Seaweed-synthesized silver nanoparticles: an eco-friendly tool in the fight against Plasmodium falciparum and its vector Anopheles stephensi?
Authors:	樋口亞紺;Murugan, Kadarkarai;Samidoss, Christina Mary;Panneerselvam, Chellasamy;Higuchi, Akon;Roni, Mathath;Suresh, Udaiyan;Chandramohan, Balamurugan;Subramaniam, Jayapal;Madhiyazhagan, Pari;Dinesh, Devakumar;Rajaganesh, Rajapandian;Alarfaj, Abdullah A.;Nicoletti, Marcello;Kumar, Suresh;Wei, Hui;Canale, Angelo;Mehlhorn, Heinz;Benelli, Giovanni
Contributors:	工學院化學工程與材料工程學系
Keywords:	adults;Animals;Anopheles;Anopheles - drug effects;Anopheles - parasitology;Anopheles stephensi;antimalarials;Biomedical and Life Sciences;Biomedicine;Chemical synthesis;Control;energy-dispersive X-ray analysis;Female;Fourier transform infrared spectroscopy;Health aspects;Immunology;inhibitory concentration 50;Insecticides - chemistry;Insecticides - metabolism;Insecticides - pharmacology;instars;Larva - drug effects;Larva - growth & development;larvae;lethal concentration 50;malaria;Malaria - parasitology;Malaria - transmission;Male;Marine algae;Medical Microbiology;Metal Nanoparticles - chemistry;Metal Nanoparticles - toxicity;Methods;Microbiology;mortality;Nanoparticles;nanosilver;Original Paper;people;plant extracts;Plasmodium falciparum;Plasmodium falciparum - physiology;Production processes;Pupa - drug effects;pupae;scanning electron microscopy;Seaweed - chemistry;Seaweed - metabolism;Silver;Silver - chemistry;Silver - metabolism;Silver - pharmacology;sustainable technology;toxicity;Ulva - chemistry;Ulva - metabolism;Ulva lactuca;X-Ray Diffraction
Date:	2015-11-26
Issue Date:	2026-04-21 14:41:49 (UTC+8)
Publisher:	Springer Verlag;Berlin/Heidelberg: Springer Berlin Heidelberg
Abstract:	摘要： Malaria, the most widespread mosquito-borne disease, affects 350–500 million people each year. Eco-friendly control tools against malaria vectors are urgently needed. This research proposed a novel method of plant-mediated synthesis of silver nanoparticles (AgNP) using a cheap seaweed extract of Ulva lactuca, acting as a reducing and capping agent. AgNP were characterized by UV–vis spectrophotometry, Fourier transform infrared (FTIR) spectroscopy, energy-dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), and X-ray diffraction (XRD). The U. lactuca extract and the green-synthesized AgNP were tested against larvae and pupae of the malaria vector Anopheles stephensi. In mosquitocidal assays, LC₅₀ values of U. lactuca extract against A. stephensi larvae and pupae were 18.365 ppm (I instar), 23.948 ppm (II), 29.701 ppm (III), 37.517 ppm (IV), and 43.012 ppm (pupae). LC₅₀ values of AgNP against A. stephensi were 2.111 ppm (I), 3.090 ppm (II), 4.629 ppm (III), 5.261 ppm (IV), and 6.860 ppm (pupae). Smoke toxicity experiments conducted against mosquito adults showed that U. lactuca coils evoked mortality rates comparable to the permethrin-based positive control (66, 51, and 41 %, respectively). Furthermore, the antiplasmodial activity of U. lactuca extract and U. lactuca-synthesized AgNP was evaluated against CQ-resistant (CQ-r) and CQ-sensitive (CQ-s) strains of Plasmodium falciparum. Fifty percent inhibitory concentration (IC₅₀) values of U. lactuca were 57.26 μg/ml (CQ-s) and 66.36 μg/ml (CQ-r); U. lactuca-synthesized AgNP IC₅₀ values were 76.33 μg/ml (CQ-s) and 79.13 μg/ml (CQ-r). Overall, our results highlighted out that U. lactuca-synthesized AgNP may be employed to develop newer and safer agents for malaria control. 其他題名： Parasitol Res 出版者： Berlin/Heidelberg: Springer Berlin Heidelberg 出版日期： 2015-11-01 出處： Parasitology Research, 2015-11, Vol.114 (11), p.4087-4097 版權： Springer-Verlag Berlin Heidelberg 2015 版權： COPYRIGHT 2015 Springer 識別號： ISSN: 0932-0113 識別號： ISSN: 1432-1955 識別號： EISSN: 1432-1955 識別號： DOI: 10.1007/s00436-015-4638-1 識別號： PMID: 26227141
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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