Synthesis and structure-activity relationships of imidazole-coumarin conjugates against hepatitis C virus

Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/101761

Title:	Synthesis and structure-activity relationships of imidazole-coumarin conjugates against hepatitis C virus
Authors:	謝發坤;Tsay, Shwu-Chen;Lin, Shu-Yu;Huang, Wen-Chieh;Hsu, Ming-Hua;Hwang, Kuo;Lin, Chun-Cheng;Horng, Jia-Cherng;Chen, I-Chia;Hwu, Jih;Shieh, Fa-Kuen;Leyssen, Pieter;Neyts, Johan
Contributors:	理學院化學學系
Keywords:	Antifungal agents;Antiviral Agents - chemical synthesis;Antiviral Agents - chemistry;Antiviral Agents - pharmacology;coumarin;Coumarins - chemical synthesis;Coumarins - chemistry;Coumarins - pharmacology;Hepacivirus - drug effects;Hepacivirus - physiology;Hepatitis;hepatitis C virus;imidazole;Imidazoles - chemical synthesis;Imidazoles - chemistry;Imidazoles - pharmacology;Molecular Structure;nitrogen heterocycles;Structure-Activity Relationship;structure–activity relationships;Virus Replication - drug effects
Date:	2016-02-01
Issue Date:	2026-04-21 14:43:25 (UTC+8)
Publisher:	MDPI Multidisciplinary Digital Publishing Institute;Switzerland: MDPI AG
Abstract:	摘要： A series of new conjugated compounds with a –SCH2– linkage were synthesized by chemical methods from imidazole and coumarin derivatives. The experimental results indicate that of the twenty newly synthesized imidazole–coumarin conjugates, three of them exhibited appealing EC50 values (5.1–8.4 μM) and selective indices >20 against hepatitis C virus. Their potency and selectivity were increased substantially by modification of their structure with two factors: imidazole nucleus with a hydrogen atom at the N(1) position and coumarin nucleus with a substituent, such as Cl, F, Br, Me, and OMe. These guidelines provide valuable information for further development of conjugated compounds as anti-viral agents. 其他題名： Molecules 出版者： Switzerland: MDPI AG 出版日期： 2016-02-18 出處： Molecules, 2016-02, Vol.21 (2), p.228 資源來源： ProQuest Publicly Available Content Database 版權： 2016. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 版權： 2016 by the authors. 2016 識別號： ISSN: 1420-3049 識別號： ISSN: 1433-1373 識別號： EISSN: 1420-3049 識別號： EISSN: 1433-1373 識別號： DOI: 10.3390/molecules21020228 識別號： PMID: 26901180
Appears in Collections:	[Department of Chemistry] journal & Dissertation

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