Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity

Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/101780

Title:	Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity
Authors:	謝發坤;Yen, Chia-I;Liu, Szu-Mam;Lo, Wei-Shang;Wu, Jhe-Wei;Liu, Yi-Hsin;Chein, Rong-Jie;Yang, Renqiang;Wu, Kevin C.-W.;Hwu, Jih Ru;Ma, Nianhan;Shieh, Fa-Kuen
Contributors:	理學院化學學系
Keywords:	Aldehydes - chemistry;Amination;Assaying;Charging;Chemistry;Correlation;Crystals;Cytotoxicity;drug carriers;Imidazoles - chemistry;Imidazoles - toxicity;In vitro methods and tests;In vitro testing;Integrity;Membranes;Metal-organic frameworks;Models, Molecular;Nanocrystals;Nanoparticles - chemistry;Perturbation;post-modification;Sulfhydryl Compounds - chemistry;Thiols;Toxicity;Uptakes;Zeolites - chemistry;Zeolites - toxicity;ZIF-90
Date:	2016-02-24
Issue Date:	2026-04-21 14:44:23 (UTC+8)
Publisher:	Wiley-VCH Verlag;Germany: Blackwell Publishing Ltd
Abstract:	摘要： Using a simple method, the aldehyde groups of zeolitic imidazolate framework‐90 (ZIF‐90) nanocrystals were converted into carboxyl, amino, and thiol groups, without affecting the integrity of the framework. Notably, for the first time, correlations between functionality and cytotoxicity are also demonstrated via in vitro cytotoxicity assays. The positive charged aminated‐ZIF‐90 presumably results in either perturbation of cell membrane, more efficient cell uptake, or both. Therefore, the half‐maximal effective (EC50) concentration of aminated‐ZIF‐90 has a higher cytotoxicity of about 30 μg mL−1. Supermodification: ZIF‐90 (zeolitic imidazolate framework‐90) nanocrystals were substituted with carboxyl, amino, and thiol groups without affecting framework integrity. In vitro cytotoxicity assays reveals that the positively charged aminated ZIF‐90 presumably results in perturbation of cell membrane and/or more efficient cell uptake. The half‐maximal effective (EC50) concentration of aminated‐ZIF‐90 has a higher cytotoxicity (ca. 30 μg mL−1). 其他題名： Chem. Eur. J 出版者： Germany: Blackwell Publishing Ltd 出版日期： 2016-02-24 出處： Chemistry : a European journal, 2016-02, Vol.22 (9), p.2925-2929 版權： 2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim 版權： 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 版權： 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 識別號： ISSN: 0947-6539 識別號： ISSN: 1521-3765 識別號： EISSN: 1521-3765 識別號： DOI: 10.1002/chem.201505005 識別號： PMID: 26756283 識別號： CODEN: CEUJED
Appears in Collections:	[Department of Chemistry] journal & Dissertation

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