Hemocompatible interface control via thermal-activated bio-inspired surface PEGylation

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題名:	Hemocompatible interface control via thermal-activated bio-inspired surface PEGylation
作者:	樋口亞紺;Sin, Mei-Chan;Lin, Wen-Lin;Chang-Hung Chen, Jeff;Higuchi, Akon;Zheng, Jie;Chinnathambi, Arunachalam;Alharbi, Sulaiman Ali;Chang, Yung
貢獻者:	工學院化學工程與材料工程學系
關鍵詞:	Bio-inspired coating;Cell adhesion & migration;Copolymers;Dopamine;hemocompatibility;material versatility;PEGylated poly(ethyleneimine);Polymerization;thermal-activated self-copolymerization
日期:	2016-05-23
上傳時間:	2026-04-21 14:52:17 (UTC+8)
出版者:	Taylor and Francis Ltd.;Philadelphia: Taylor & Francis
摘要:	摘要： A facile thermal-activated self-copolymerization coating of antifouling layers was designed. PEGylated poly(ethyleneimine) (PEI-PEGMA) was first synthesized, mixed with an alkaline dopamine solution, and then concurrently codeposited onto versatile substrates of both organic and inorganic materials. Thermal-activated codeposition of dopamine/PEI-PEGMA could then proceed, giving rise to good hemocompatible performance in respect to low fibrinogen adsorption, ultra-low blood cell adhesion and activation, and almost undetectable hemolytic activities. This work also revealed that the hemocompatible performance was contributed by PEGylated PEI but not dopamine, as the poly(dopamine)-coating was shown to induce a high level of fibrinogen adsorption as well as vigorous platelet activation. 出版者： Philadelphia: Taylor & Francis 出版日期： 2016-05-23 出處： International journal of polymeric materials, 2016-05, Vol.65 (8), p.409-420 資源來源： EBSCOhost Academic Search Premier 版權： Copyright © Taylor & Francis Group, LLC 2016 版權： Copyright © Taylor & Francis Group, LLC 識別號： ISSN: 0091-4037 識別號： ISSN: 1026-7751 識別號： ISSN: 1563-535X 識別號： EISSN: 1563-535X 識別號： DOI: 10.1080/00914037.2015.1129953
顯示於類別:	[化學工程與材料工程學系 ] 期刊論文

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