Eco-friendly drugs from the marine environment: spongeweed-synthesized silver nanoparticles are highly effective on Plasmodium falciparum and its vector Anopheles stephensi, with little non-target effects on predatory copepods

NCUIR > Engineering College > Department of Chemical and Materials Engineering > journal & Dissertation > Item 987654321/101966

Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/101966

Title:	Eco-friendly drugs from the marine environment: spongeweed-synthesized silver nanoparticles are highly effective on Plasmodium falciparum and its vector Anopheles stephensi, with little non-target effects on predatory copepods
Authors:	樋口亞紺;Murugan, Kadarkarai;Panneerselvam, Chellasamy;Subramaniam, Jayapal;Madhiyazhagan, Pari;Hwang, Jiang-Shiou;Wang, Lan;Dinesh, Devakumar;Suresh, Udaiyan;Roni, Mathath;Higuchi, Akon;Nicoletti, Marcello;Benelli, Giovanni
Contributors:	工學院化學工程與材料工程學系
Keywords:	agar;Algae;Animals;Anopheles - drug effects;Anopheles stephensi;Aquatic insects;Aquatic Pollution;Artemisinin;Atmospheric Protection/Air Quality Control/Air Pollution;Bacillus subtilis;Biological control;Biology;Chlorophyta - chemistry;Chloroquine;Codium;Codium tomentosum;Control programs;Copepoda;Copepoda - drug effects;Crustaceans;Developmental stages;Drug dosages;Earth and Environmental Science;Ecotoxicology;energy-dispersive X-ray analysis;Environment;Environmental Chemistry;Environmental Health;Environmental science;Fever;Fourier transform infrared spectroscopy;Fourier transforms;growth retardation;Humans;Infrared spectroscopy;inhibitory concentration 50;insect vectors;Insect Vectors - drug effects;Insecticides - chemistry;instars;Klebsiella pneumoniae;Larva - drug effects;Larvae;lethal concentration 50;Malaria;Marine environment;Mesocyclops aspericornis;Metabolites;Metal Nanoparticles - chemistry;microbial pesticides;Minimum inhibitory concentration;Mosquito Control;mosquito-borne diseases;Mosquitoes;Nanoparticles;nanosilver;Nanotechnology;Natural products;Parasite resistance;Parasites;Pathogens;Pest resistance;Pesticides;Plant Extracts - pharmacology;Plant Leaves - metabolism;Plasmodium;Plasmodium falciparum;Plasmodium falciparum - drug effects;Predation;Pupa - drug effects;pupae;Research Article;Salmonella Typhi;Scanning electron microscopy;Seaweed - chemistry;Seaweeds;Shellfish;Silver;Silver - chemistry;Silver - pharmacology;Spectrum analysis;Studies;Tropical diseases;Ultraviolet spectroscopy;Vector-borne diseases;Vectors;Vectors (Biology);Waste Water Technology;Water Management;Water Pollution Control;X-ray diffraction;X-ray spectroscopy
Date:	2016-08-01
Issue Date:	2026-04-21 14:53:08 (UTC+8)
Publisher:	Springer Science + Business Media;Berlin/Heidelberg: Springer Berlin Heidelberg
Abstract:	摘要： Mosquitoes act as vectors of devastating pathogens and parasites, representing a key threat for millions of humans and animals worldwide. The control of mosquito-borne diseases is facing a number of crucial challenges, including the emergence of artemisinin and chloroquine resistance in Plasmodium parasites, as well as the presence of mosquito vectors resistant to synthetic and microbial pesticides. Therefore, eco-friendly tools are urgently required. Here, a synergic approach relying to nanotechnologies and biological control strategies is proposed. The marine environment is an outstanding reservoir of bioactive natural products, which have many applications against pests, parasites, and pathogens. We proposed a novel method of seaweed-mediated synthesis of silver nanoparticles (AgNP) using the spongeweed Codium tomentosum, acting as a reducing and capping agent. AgNP were characterized by UV–Vis spectroscopy, Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD). In mosquitocidal assays, the 50 % lethal concentration (LC 50 ) of C. tomentosum extract against Anopheles stephensi ranged from 255.1 (larva I) to 487.1 ppm (pupa). LC 50 of C. tomentosum -synthesized AgNP ranged from 18.1 (larva I) to 40.7 ppm (pupa). In laboratory, the predation efficiency of Mesocyclops aspericornis copepods against A. stephensi larvae was 81, 65, 17, and 9 % (I, II, III, and IV instar, respectively). In AgNP contaminated environment, predation was not affected; 83, 66, 19, and 11 % (I, II, III, and IV). The anti-plasmodial activity of C. tomentosum extract and spongeweed-synthesized AgNP was evaluated against CQ-resistant (CQ-r) and CQ-sensitive (CQ-s) strains of Plasmodium falciparum . Fifty percent inhibitory concentration (IC 50 ) of C. tomentosum were 51.34 μg/ml (CQ-s) and 65.17 μg/ml (CQ-r); C. tomentosum -synthesized AgNP achieved IC 50 of 72.45 μg/ml (CQ-s) and 76.08 μg/ml (CQ-r). Furthermore, low doses of the AgNP inhibited the growth of Bacillus subtilis, Klebsiella pneumoniae, and Salmonella typhi , using the agar disk diffusion and minimum inhibitory concentration protocol. Overall, C. tomentosum metabolites and spongeweed-synthesized AgNP may be potential candidates to develop novel and effective tools in the fight against Plasmodium parasites and their mosquito vectors. The employ of ultra-low doses of nanomosquitocides in synergy with cyclopoid crustaceans seems a promising green route for effective mosquito control programs. 其他題名： Environ Sci Pollut Res 其他題名： Environ Sci Pollut Res Int 出版者： Berlin/Heidelberg: Springer Berlin Heidelberg 出版日期： 2016-08-01 出處： Environmental science and pollution research international, 2016-08, Vol.23 (16), p.16671-16685 資源來源： Agricultural & Environmental Science Collection 版權： Springer-Verlag Berlin Heidelberg 2016 識別號： ISSN: 0944-1344 識別號： ISSN: 1614-7499 識別號： EISSN: 1614-7499 識別號： DOI: 10.1007/s11356-016-6832-9 識別號： PMID: 27180838
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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