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https://ir.lib.ncu.edu.tw/handle/987654321/101970
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| 題名: | Zwitterionic fibrous polypropylene assembled with amphiphatic carboxybetaine copolymers for hemocompatible blood filtration |
| 作者: | 樋口亞紺;Venault, Antoine;Ye, Chih-Chen;Lin, Yi-Cun;Tsai, Ching-Wei;Jhong, Jheng-Fong;Ruaan, Ruoh-Chyu;Higuchi, Akon;Chinnathambi, Arunachalam;Ho, Hsin-Tsung;Chang, Yung |
| 貢獻者: | 工學院化學工程與材料工程學系 |
| 關鍵詞: | Amphiphatic copolymer;Antifouling properties;Betaine - chemistry;Blood;Blood cells;Blood filtration;Blood Platelets - metabolism;Coating;Copolymers;Ethylamines - chemistry;Evaporation;Filtration;Hemocompatible polypropylene membrane;Hemofiltration;Humans;Materials Testing;Membranes;Membranes, Artificial;Methacrylates - chemistry;Platelet Activation;Polypropylenes;Polypropylenes - chemistry;Solvent evaporation |
| 日期: | 2016-08-01 |
| 上傳時間: | 2026-04-21 14:53:15 (UTC+8) |
| 出版者: | Elsevier BV;England: Elsevier Ltd |
| 摘要: | 摘要： [Display omitted] The present study serves three main functions. First, it presents a novel random copolymer, made of octadecyl acrylate hydrophobic blocks and 2-(dimethylamino)ethyl methacrylate hydrophilic groups, and it zwitterionic form. Second, random copolymer and zwitterionic random copolymer, OmDn and Z-OmDn, are used to modify polypropylene membranes by evaporation coating. Our investigations unveil that this method leads to sufficiently stable self-assembling provided a minimum number of hydrophobic repeat units of 77, which also corresponds to a hydrophobic degree of 74%. Third, antifouling and hemocompatible properties of membranes are thoroughly investigated using all types of blood cells separately, as well as challenging membranes against whole blood in static and dynamic conditions. Membranes modified with zwitterionic copolymer containing 26% of zwitterionic groups are shown to be highly antifouling and hemocompatible, for a coating density as low as 0.2mg/cm2. Their application in a specially designed blood filtration module enabled to almost totally inhibit blood cells interactions with membrane material, as well as to importantly reduce platelet activation in the permeate (2.5-fold reduction). The design of new zwitterionic copolymer material is proposed and demonstrated in this study. It was showed that hydrophobicoctadecyl acrylate segments can be introduced in the zwitterioniccarboxybetaine polymer chain with a well-controlled random sequence. Stable, efficient, and effective surface zwitterionization of hydrophobic polypropylene are obtained via grafting onto approach by evaporation-induced self-assembling coating. In the perspective of potential application, hemocompatible blood filtration was demonstrated with the excellent results of non-activated platelets obtained. Design: New zwitterionicmaterial, amphiphatic carboxybetaine copolymers. Development: Evaporation-induced self-assembling grafting. Application: Hemocompatible blood filtration.
其他題名： Acta Biomater
出版者： England: Elsevier Ltd
出版日期： 2016-08-01
出處： Acta biomaterialia, 2016-08, Vol.40, p.130-141
版權： 2016 Acta Materialia Inc.
版權： Copyright © 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
識別號： ISSN: 1742-7061
識別號： ISSN: 1878-7568
識別號： EISSN: 1878-7568
識別號： DOI: 10.1016/j.actbio.2016.01.031
識別號： PMID: 26826530 |
| 顯示於類別: | [化學工程與材料工程學系 ] 期刊論文
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