Revisit the Correlation between the Elastic Mechanics and Fusion of Lipid Membranes

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Title:	Revisit the Correlation between the Elastic Mechanics and Fusion of Lipid Membranes
Authors:	陳儀帆;Fan, Zih-An;Tsang, Kuan-Yu;Chen, Si-Han;Chen, Yi-Fan
Contributors:	工學院化學工程與材料工程學系
Keywords:	631/57/2271;639/301/923/966;639/638/440/951;639/766/36/1124;639/766/747;Elastic properties;Energy;Humanities and Social Sciences;Hydration;Intermediates;Lipid composition;Lipid membranes;Lipids;Mechanics;Membrane fusion;Membranes;multidisciplinary;Phase transitions;Proteins;Science
Date:	2016-08-18
Issue Date:	2026-04-21 14:53:42 (UTC+8)
Publisher:	Nature Publishing Group;London: Nature Publishing Group UK
Abstract:	摘要： Membrane fusion is a vital process in key cellular events. The fusion capability of a membrane depends on its elastic properties and varies with its lipid composition. It is believed that as the composition varies, the consequent change in C 0 (monolayer spontaneous curvature) is the major factor dictating fusion, owing to the associated variation in G E s (elastic energies) of the fusion intermediates (e.g. stalk). By exploring the correlations among fusion, C 0 and K cp (monolayer bending modulus), we revisit this long-held belief and re-examine the fusogenic contributions of some relevant factors. We observe that not only C 0 but also K cp variations affect fusion, with depression in K cp leading to suppression in fusion. Variations in G E s and inter-membrane interactions cannot account for the K cp -fusion correlation; fusion is suppressed even as the G E s decrease with K cp , indicating the presence of factor(s) with fusogenic importance overtaking that of G E . Furthermore, analyses find that the C 0 influence on fusion is effected via modulating G E of the pre-fusion planar membrane, rather than stalk. The results support a recent proposition calling for a paradigm shift from the conventional view of fusion and may reshape our understanding to the roles of fusogenic proteins in regulating cellular fusion machineries. 其他題名： Sci Rep 出版者： London: Nature Publishing Group UK 出版日期： 2016-08-18 出處： Scientific reports, 2016-08, Vol.6 (1), p.31470, Article 31470 資源來源： Publicly Available Content Database 版權： The Author(s) 2016 版權： Copyright Nature Publishing Group Aug 2016 版權： Copyright © 2016, The Author(s) 2016 The Author(s) 識別號： ISSN: 2045-2322 識別號： EISSN: 2045-2322 識別號： DOI: 10.1038/srep31470 識別號： PMID: 27534263
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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