Statistical model and inference for pharmacokinetic data

NCUIR > Research Center > CENTER FOR ASTRONAUTICAL PHYSICS AND ENGINEERING (CAPE) > journal & Dissertation > Item 987654321/102173

Please use this identifier to cite or link to this item: https://ir.lib.ncu.edu.tw/handle/987654321/102173

Title:	Statistical model and inference for pharmacokinetic data
Authors:	陳玉英;Chen, Yuh-Ing;Lin, Wen-Ming
Contributors:	太空科學與科技研究中心
Keywords:	Computer simulation;Confidence intervals;Construction;drug concentration-time profile;Drugs;Inference;Mathematical models;multivariate generalized gamma distribution;one-compartment pharmacokinetic model;Pharmacology;Probability distribution;Probability distribution functions;Simulation;Statistical analysis;Statistical methods
Date:	2014-01-01
Issue Date:	2026-04-23 11:03:43 (UTC+8)
Publisher:	Taylor and Francis Ltd.;Abingdon: Taylor & Francis
Abstract:	摘要： In this paper, we consider a statistical model for the drug concentration-time profiles that are obtained in a pharmacokinetic (PK) study when the drug is orally administered. In the proposed statistical PK model, the subject-specific concentration-time curve is described by the one-compartment PK model with first-order absorption and elimination. Moreover, a multivariate generalized gamma distribution is developed for the joint distribution of the drug concentrations that are repeatedly measured from the same subject. We then construct confidence intervals for the subject-exposure parameters which provide a further insight into the individual exposure of the drug under study. The proposed statistical PK model and the associated inference are then applied to illustrate a real data set. A simulation study is also implemented to investigate the performances of the coverage probability and expected length of the proposed confidence intervals. Finally, we give conclusions and discussions on the application of the proposed procedures. 出版者： Abingdon: Taylor & Francis 出版日期： 2014-12-02 出處： Journal of statistical computation and simulation, 2014-12, Vol.84 (12), p.2607-2618 版權： 2013 Taylor & Francis 2013 版權： Copyright Taylor & Francis Ltd. 2014 識別號： ISSN: 0094-9655 識別號： EISSN: 1563-5163 識別號： DOI: 10.1080/00949655.2013.798734
Appears in Collections:	[CENTER FOR ASTRONAUTICAL PHYSICS AND ENGINEERING (CAPE)] journal & Dissertation

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	21	View/Open

社群 sharing

Loading...