BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior

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Title:	BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior
Authors:	范世榮;Corrigan, Laura;Redhai, Siamak;Leiblich, Aaron;Fan, Shih-Jung;Perera, Sumeth M.W.;Patel, Rachel;Gandy, Carina;Wainwright, S. Mark;Morris, John F.;Hamdy, Freddie;Goberdhan, Deborah C.I.;Wilson, Clive
Contributors:	生醫理工學院生命科學系
Keywords:	Animal behavior;Animals;Bone Morphogenetic Proteins - physiology;Cellular biology;Drosophila melanogaster;Drosophila Proteins - physiology;Epithelial Cells - metabolism;Exosomes - physiology;Female;Females;Genitalia, Female - cytology;Genitalia, Male - metabolism;Insects;Lysosomes - metabolism;Male;Membrane Fusion;Membrane Microdomains - metabolism;Multivesicular Bodies - metabolism;Peptides;Protein Transport;Proteins;Reproduction;Reproductive system;Secretory Vesicles - metabolism;Sexual Behavior, Animal;Signal Transduction;Spermatozoa - metabolism;Tetraspanin 30 - metabolism;Vacuoles - metabolism
Date:	2014-01-01
Issue Date:	2026-04-23 11:11:51 (UTC+8)
Publisher:	Rockefeller University Press;United States: Rockefeller University Press
Abstract:	摘要： Male reproductive glands secrete signals into seminal fluid to facilitate reproductive success. In Drosophila melanogaster, these signals are generated by a variety of seminal peptides, many produced by the accessory glands (AGs). One epithelial cell type in the adult male AGs, the secondary cell (SC), grows selectively in response to bone morphogenetic protein (BMP) signaling. This signaling is involved in blocking the rapid remating of mated females, which contributes to the reproductive advantage of the first male to mate. In this paper, we show that SCs secrete exosomes, membrane-bound vesicles generated inside late endosomal multivesicular bodies (MVBs). After mating, exosomes fuse with sperm (as also seen in vitro for human prostate-derived exosomes and sperm) and interact with female reproductive tract epithelia. Exosome release was required to inhibit female remating behavior, suggesting that exosomes are downstream effectors of BMP signaling. Indeed, when BMP signaling was reduced in SCs, vesicles were still formed in MVBs but not secreted as exosomes. These results demonstrate a new function for the MVB–exosome pathway in the reproductive tract that appears to be conserved across evolution. 其他題名： J Cell Biol 出版者： United States: Rockefeller University Press 出版日期： 2014-09-01 出處： Journal of Cell Biology, 2014-09, Vol.206 (5), p.671-688 資源來源： Alma/SFX Local Collection 版權： 2014 Corrigan et al. 版權： Copyright Rockefeller University Press Sep 1, 2014 版權： 2014 Corrigan et al. 2014 識別號： ISSN: 0021-9525 識別號： ISSN: 1540-8140 識別號： EISSN: 1540-8140 識別號： DOI: 10.1083/jcb.201401072 識別號： PMID: 25154396 識別號： CODEN: JCLBA3
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